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Merck

PHR1182

Supelco

罂粟碱 盐酸盐

Pharmaceutical Secondary Standard; Certified Reference Material

别名:

6,7-Dimethoxy-1-veratrylisoquinoline hydrochloride

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About This Item

经验公式(希尔记法):
C20H21NO4 · HCl
CAS号:
分子量:
375.85
Beilstein:
3921435
EC號碼:
MDL號碼:
分類程式碼代碼:
41116107
PubChem物質ID:
NACRES:
NA.24

等級

certified reference material
pharmaceutical secondary standard

品質等級

agency

traceable to BP 277
traceable to Ph. Eur. P0270000
traceable to USP 1496008

API 家族

papaverine

CofA

current certificate can be downloaded

技術

HPLC: suitable
gas chromatography (GC): suitable

應用

food and beverages
pharmaceutical (small molecule)

格式

neat

儲存溫度

2-30°C

SMILES 字串

COC1=C(OC)C=C(C(CC2=CC(OC)=C(OC)C=C2)=NC=C3)C3=C1.Cl

InChI

1S/C20H21NO4.ClH/c1-22-17-6-5-13(10-18(17)23-2)9-16-15-12-20(25-4)19(24-3)11-14(15)7-8-21-16;/h5-8,10-12H,9H2,1-4H3;1H

InChI 密鑰

UOTMYNBWXDUBNX-UHFFFAOYSA-N

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一般說明

Papaverine hydrochloride is the hydrochloride salt of an opiate derivative called papaverine, a benzylisoquinoline compound. It has been found to relax smooth muscles of blood vessels and is used in the management of occlusivity and spasticity of pulmonary, coronary and peripheral arteries.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

應用

Papaverine hydrochloride is used as a pharmaceutical reference standard in the determination of the analyte in pharmaceutical formulations by chromatographic and spectrophotometric techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

生化/生理作用

Smooth muscle relaxant and cerebral vasodilator; phosphodiesterase inhibitor.

分析報告

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

其他說明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

腳註

To see an example of a Certificate of Analysis for this material enter LRAA9001 in the slot below. This is an example certificate only and may not be the lot that you receive.

推薦產品

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

象形圖

Skull and crossbones

訊號詞

Danger

危險聲明

危險分類

Acute Tox. 3 Oral

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類(WGK)

WGK 1

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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分析证书(COA)

Lot/Batch Number

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访问文档库

Simultaneous determination of dipyrone and papaverine in pharmaceutical formulation using PLS regression and UV spectrophotometry
do Nascimento AP, et al.
Analytical Letters, 40(5), 975-986 (2007)
The effect of intravenous papaverine hydrochloride on the cerebral circulation
Jayne H W, et al
The Journal of Clinical Investigation, 31(1), 111-114 (1952)
Spectrophotometric determination of meclozine HCl and papaverine HCl in their pharmaceutical formulations
Abdel-Ghani NT, et al.
Journal of Pharmaceutical and Biomedical Analysis, 28(2), 373-378 (2002)
Alaa El-Gindy
Farmaco (Societa chimica italiana : 1989), 60(9), 745-753 (2005-07-19)
Three methods are developed for the simultaneous determination of diprophylline (DP), phenobarbitone (PH) and papaverine hydrochloride (PP). The chromatographic method depends on a high performance liquid chromatographic (HPLC) separation on a reversed-phase C18 column with a mobile phase consisting of
Simultaneous assay of ephedrine hydrochloride, theophylline, papaverine hydrochloride and hydroxyzine hydrochloride in tablets using RP-LC
Boberi B, et al.
Journal of Pharmaceutical and Biomedical Analysis, 21(1), 15-22 (1999)

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