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P1754

Sigma-Aldrich

TWEEN ® 80

TWEEN® 80

viscous liquid

别名:

吐温80(TWEEN® 80), POE (20)山梨糖醇酐单油酸酯, 聚乙二醇山梨醇酐单油酸酯, 聚山梨酯 80, 聚氧乙烯山梨糖醇酐单油酸酯

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About This Item

CAS号:
9005-65-6
MDL编号:
MFCD00082107
UNSPSC代码:
12161900
NACRES:
NA.21
价格与库存信息目前不能提供

生物来源

Porcine (tallow)
bovine (tallow)

质量水平

200

描述

non-ionic

表单

viscous liquid

分子量

micellar avg mol wt 79,000
average mol wt 1310

组成

Oleic acid, ≥58.0% (balance primarily linoleic, palmitic, and stearic acids)

聚集数

60

CMC

0.012 mM (20-25°C)

粘度

400-620 mPa.s

转变温度

cloud point 65 °C

溶解性

water: soluble, clear to slightly hazy, colorless to yellow

密度

1.064 g/cm3

HLB

15

应用

cell analysis

SMILES字符串

CCCCCCCC/C=C/CCCCCCCC(=O)OCCOCC(C1C(CC(O1)OCCO)OCCO)OCCO

InChI

1S/C32H60O10/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-30(36)40-25-24-37-27-29(39-22-19-34)32-28(38-21-18-33)26-31(42-32)41-23-20-35/h9-10,28-29,31-35H,2-8,11-27H2,1H3/b10-9+

InChI key

RGPBUVUVZKQNHD-MDZDMXLPSA-N

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相关类别

一般描述

吐温® 80 是一种非离子去污剂和表面活性剂，属于山梨聚糖油酸酯。它是一种多功能化合物，常用于各种生物学应用，包括细胞裂解、核分离和细胞分级分离。此外，吐温®80可用于稳定蛋白质，并有助于蛋白质膜研究。其功效来源于聚山梨醇酯基团，该基团的特点是山梨醇和山梨聚糖油酸酯与聚乙二醇链的结合。这些结构特性造就了吐温® 80′的乳化能力和广泛应用。

应用

TWEEN® 80已用于小鼠和大鼠中特异性注射中的药物载体溶液。[1][2]它已用于测定细菌细胞中酯酶的活性。[3]
用于从哺乳动物细胞系中选择性提取蛋白质、分离细胞核的非离子型去垢剂。

生化/生理作用

TWEEN® 80是一种可助力于蛋白质稳定和蛋白质膜研究的聚山梨醇酯表面活性剂。它常用于进行膜蛋白的提取以及从细胞中进行细胞核分离。[4][5][6]

特点和优势

  • 优良的润湿和分散剂
  • 适用于细胞生物学和生物化学研究的多功能表面活性剂

其他说明

如需了解生化试剂系列的更多信息，请填写此表。

法律信息

TWEEN is a registered trademark of Croda International PLC

储存分类代码

10 - Combustible liquids

WGK

WGK 1

闪点(°F)

>235.4 °F - closed cup

闪点(°C)

> 113 °C - closed cup

个人防护装备

Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
BCCM9515
BCCM7843
BCCM6321
BCCM3263
BCCL4939

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Questions

1–10 of 11 Questions  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  3. This material is free of residual solvents?

    1 answer

    1. This product is not tested for residual solvents. Should this be a requirement, see product 817061, which is tested for Ethylene Oxide, 1,4-Dioxane, and Ethylene glycol. Please see the link below to review this item:
      https://www.sigmaaldrich.com/product/mm/817061

      Helpful?

  4. What is the boiling point of this specific Tween 80 product?

    1 answer

    1. This product is not tested for boiling point. However, various reference sources cite a boiling point of approximately 100°C.

      Helpful?

  5. Hello, Is there an expiration date or retest date for this product?

    1 answer

    1. This product is not assigned an expiration date. It is assigned a recommended retest date of approximately 4 years after the quality release date. A recommended retest date is the time during which the product is expected to remain within established stability specifications, provided that it has been stored under defined conditions. After the Retest Date, product samples should be examined to ensure that the product is still in compliance with the established specifications.

      For more information, you may access the "Product Dating Information" document under "ADDITIONAL USEFUL DOCUMENTS ABOUT OUR PRODUCTS" at the bottom of the Quality Services page with this link: https://www.sigmaaldrich.com/US/en/life-science/quality-and-regulatory-management/quality-services.

      Helpful?

  6. Is Product P1754, TWEEN® 80, sterile?

    1 answer

    1. The product is not sterile. Autoclaving a solution of TWEEN 80 is generally not advised. Sterile filtration is more easily done if the liquid is warmed to about 40°C and alternate portions of hot distilled water and TWEEN 80 are poured through the 0.22 μm filter. The TWEEN 80 will blend and remain in solution.

      Helpful?

  7. Is it normal for the color of Product P1754, TWEEN® 80, to change from lot to lot?

    1 answer

    1. Yes. According to Sigma-Aldrich's specifications, Product No. P1754 can appear bright yellow to yellow with a green cast.  Please see our Specification Sheet for more information.

      Helpful?

  8. What is the Critical Micelle Concentration (CMC) of Product P1754, TWEEN® 80?

    1 answer

    1. The CMC value is 13-15 mg/Liter.

      Helpful?

  9. What is the Department of Transportation shipping information for this product?

    1 answer

    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

      Helpful?

  10. Is Product P1754, TWEEN® 80, tested for RNase and DNase activity?

    1 answer

    1. No. Product P1754 is not tested for contaminating RNase and DNase activity.  Product P5188 is a Molecular Biology grade product that has been tested for DNase and RNase.

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1–10 of 11 Questions  

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