This product is sold by the International Unit (IU). The minimum activity of 6000 units per milligram is reported based on the dried weight of the powder. The maximum allowable moisture content at 7%. The amount of material in each vial varies from lot to lot and can be determined by dividing the number of units of the package size by the lot-specific activity. This information is reported in the product Certificate of Analysis. Please see the link below to review a sample or lot specific Certificate:
https://www.sigmaaldrich.com/product/sial/p1004#product-documentation
所有图片(2)
About This Item
经验公式（希尔记法）:
C55H96N16O13 · 2H2SO4
CAS号:
分子量:
1385.61
EC號碼:
MDL號碼:
分類程式碼代碼:
51283106
NACRES:
NA.76
价格与库存信息目前不能提供
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生物源
Pseudomonas aeruginosa
品質等級
形狀
powder
儲存條件
(Tightly closed. Dry. )
溶解度
water: 50 mg/mL
抗生素活性譜
Gram-negative bacteria
fungi
作用方式
cell membrane | interferes
儲存溫度
2-8°C
SMILES 字串
O=C(C(NC(C(CCN)NC(CCCCC(C)CC)=O)=O)C(C)O)NC(CCN)C(NC(CCNC(C(NC(C(NC(C(CCN)N1)=O)CCN)=O)C(O)C)=O)C(NC(CCN)C(NC(CC2=CC=CC=C2)C(NC(CC(C)C)C1=O)=O)=O)=O)=O.O=S(O)(O)=O
InChI
1S/C48H82N16O13.H2O4S/c1-27(2)24-37-47(76)59-32(11-19-52)41(70)56-31(10-18-51)43(72)61-35(14-22-65)39(68)54-21-13-34(45(74)57-33(12-20-53)44(73)64-38(48(77)63-37)25-28-6-4-3-5-7-28)60-42(71)30(9-17-50)58-46(75)36(15-23-66)62-40(69)29(8-16-49)55-26-67;1-5(2,3)4/h3-7,26-27,29-38,65-66H,8-25,49-53H2,1-2H3,(H,54,68)(H,55,67)(H,56,70)(H,57,74)(H,58,75)(H,59,76)(H,60,71)(H,61,72)(H,62,69)(H,63,77)(H,64,73);(H2,1,2,3,4)
InChI 密鑰
HNDFYNOVSOOGDU-UHFFFAOYSA-N
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相关类别
一般說明
硫酸多粘菌素B是一种强阳离子环状多肽抗生素，由多粘菌发酵而来。它是B1和B2硫酸盐的混合物。
應用
硫酸多粘菌素B是一种强阳离子环状多肽抗生素，由 多粘菌发酵而来。 它是B1和B2硫酸盐的混合物。 该产品已应用于临床治疗 铜绿假单胞菌†敏感株感染引起的尿路感染、脑膜感染和血流感染。 它还用于研究多药耐药病原体††，作为一种去除内毒素的固定化剂，并诱导从切除的高粱根的皮层细胞的细胞膜上形成孔。
生化／生理作用
作用机制：多粘菌素B硫酸盐结合到细菌脂多糖的脂质部分†上，通过诱导足够大的孔来破坏细胞质膜，使核苷酸泄漏到细菌的细胞壁中。 这可破环细胞质膜的半透性。
抗菌谱：对大多数革兰氏阴性杆菌，包括 大肠杆菌 ，真菌和革兰氏阳性菌都有杀菌作用。
抗菌谱：对大多数革兰氏阴性杆菌，包括 大肠杆菌 ，真菌和革兰氏阳性菌都有杀菌作用。
多粘菌素B是用于治疗革兰氏阴性菌感染的最重要抗生素之一，适于治疗由耐碳青霉烯的非发酵罐细菌和耐碳青霉烯的肠杆菌科细菌等引起的感染[4]。
特點和優勢
适合多种研究应用的高质量抗生素
準備報告
硫酸多粘菌素B溶于50 mg/mL的水中，产生一种稍有雾状的无色至黄色溶液。 它仅微溶于任何有机溶剂。 例如，它在乙醇中的溶解度为0.115 mg/mL。
原液应无菌过滤并在2-8°C条件下储存。 在37°C条件下可稳定保存 5 天。
原液应无菌过滤并在2-8°C条件下储存。 在37°C条件下可稳定保存 5 天。
儲存和穩定性
参照产品交付时的条件，应在2-8°C条件下避光保存本产品。储存在这些条件下，产品留样3年后′未见变化。
訊號詞
Warning
危險聲明
危險分類
Acute Tox. 4 Oral
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
dust mask type N95 (US), Eyeshields, Gloves
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
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We're needing a little more information on how this product is sold. What size are the "units" that are mentioned, and can you provide any details as to the concentration of chemical in the unit? Thank you!
1 answer-
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Dear Sir, May I ask what's meaning of 10 MU? How many grams per bottle? Tks.
1 answer-
The 10 MU stands for a 10,000,000 unit package size. The mass contained in each bottle is lot-specific and dependent on the activity. This activity is reported on the certificate of analysis. For example, lot number 0000227415 tested at 8232 units per milligram. A 10 MU package size would amount to 1.214 grams. See the link below to review this Certificate of Analysis: https://www.sigmaaldrich.com/certificates/sapfs/PROD/sap/certificate_pdfs/COFA/Q14/P1004-50MU0000227415.pdf
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