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Merck
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文件

A8456

Sigma-Aldrich

4-（2-氨乙基）苯磺酰氟 盐酸盐

≥97.0% (HPLC)

别名:

AEBSF

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About This Item

经验公式（希尔记法）:
C8H10FNO2S · HCl
CAS号:
30827-99-7
分子量:
239.69
Beilstein:
7604627
MDL號碼:
MFCD00132962
分類程式碼代碼:
12352202
PubChem物質ID:
24278240
NACRES:
NA.77

生物源

synthetic (organic)

品質等級

300

化驗

≥97.0% (HPLC)

形狀

powder

mp

183-191  °C

溶解度

H2O: 50 mg/mL

儲存溫度

−20°C

SMILES 字串

FS(C1=CC=C(CCN)C=C1)(=O)=O.[H]Cl

InChI

1S/C8H10FNO2S.ClH/c9-13(11,12)8-3-1-7(2-4-8)5-6-10;/h1-4H,5-6,10H2;1H

InChI 密鑰

WRDABNWSWOHGMS-UHFFFAOYSA-N

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一般說明

stable for up to six months if stored refrigerated at a pH of less than 7. If a pH of greater than 7 is required, pH adjustment should be made just prior to use.

應用

4-（2-氨乙基）苯磺酰氟盐酸盐（AEBSF）已用作：
  • 血浆样品中的蛋白酶抑制剂，以防止酰基化胃饥饿素（AG）降解
  • SVSP抑制或AEBSF测定中的蛇毒丝氨酸蛋白酶（SVSP）抑制剂，以测定SVSP的参与度对纤维蛋白原凝血活性的影响
  • NP-40裂解缓冲液的组分，以重悬细胞微球制备细胞裂解物

建议使用浓度为 0.1 至 1mM。

生化／生理作用

AEBSF可抑制乙酰胆碱酯酶（AChE）。
4-（2-氨乙基）苯磺酰氟盐酸盐（AEBSF）是一种不可逆丝氨酸蛋白酶抑制剂。抑制常数与苯甲磺酰氟（PMSF）和二异丙基氟磷酸（DFP）相似。 经证实，AEBSF可抑制胰蛋白酶、胰凝乳蛋白酶、纤溶酶、激肽释放酶和凝血酶。作为PMSF和DFP的替代品，AEBSF具有较低的毒性，并提高了在水中的溶解性和水溶液中的稳定性。AEBSF可用于浓度高达0.25 mM的细胞培养。

象形圖

Corrosion
GHS05

訊號詞

Danger

危險聲明

H314

危險分類

Eye Dam. 1 - Skin Corr. 1A

儲存類別代碼

8A - Combustible corrosive hazardous materials

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

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分析证书(COA)

Lot/Batch Number
0000389739
0000389740
0000359853
069M4058V
0000183439

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