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Merck

410225

Sigma-Aldrich

甘氨酸

≥98.5%, ACS reagent for peptide synthesis

别名:

氨基乙酸, 甘氨酸

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About This Item

线性分子式:
NH2CH2COOH
CAS号:
分子量:
75.07
Beilstein:
635782
EC 号:
MDL编号:
UNSPSC代码:
12352209
eCl@ss:
32160406
PubChem化学物质编号:
NACRES:
NA.21
价格与库存信息目前不能提供

产品名称

甘氨酸, ACS reagent, ≥98.5%

等级

ACS reagent

质量水平

方案

≥98.5%

表单

powder, crystals or granules

杂质

H2SO4, passes test (darkened)
Hydrolyzable subsances, passes test

灼烧残渣

≤0.1%

颜色

white

pKa (25 °C)

(1) 2.35, (2) 9.60
2.35

mp

240 °C (dec.) (lit.)

痕量阴离子

chloride (Cl-): ≤0.005%
sulfate (SO42-): ≤0.005%

痕量阳离子

NH4+: ≤0.005%
heavy metals: ≤0.002% (by ICP)

应用

peptide synthesis

官能团

amine
carboxylic acid

SMILES字符串

NCC(O)=O

InChI

1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5)

InChI key

DHMQDGOQFOQNFH-UHFFFAOYSA-N

基因信息

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一般描述

甘氨酸是最简单的氨基酸结构单元。

应用

甘氨酸用于全细胞膜片钳记录,以测量NMDA(N-甲基-D-天冬氨酸)内向电流。[1]它还用作结晶学中的模型有机系统,展示新型声学雾化平台。[2]

生化/生理作用

甘氨酸是非必需氨基酸。[3]通过细胞膜的钙内流由甘氨酸门控通道介导。甘氨酸参与卟啉、嘌呤和丝氨酸的合成。它还可作为谷氨酸与NMDA(N-甲基-D-天冬氨酸)受体结合的竞争性激动剂。[4]在快速增殖的癌细胞中,由于对氨基酸的需求增加,甘氨酸合成可能会增加。[3]
脊髓中的抑制性神经递质,NMDA受体的变构调节器。

储存分类代码

11 - Combustible Solids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Controversial Effects of D-Amino Acid Oxidase Activator (DAOA)/G72 on D-Amino Acid Oxidase (DAO) Activity in Human Neuronal, Astrocyte and Kidney Cell Lines: The N-methyl D-aspartate (NMDA) Receptor Hypofunction Point of View
Vinita Jagannath
Frontiers in Molecular Neuroscience (2017)
A Novel Acoustomicrofluidic Nebulization Technique Yielding New Crystallization Morphologies
Heba Ahmed
Advanced Materials, 30(3) (2018)
Amino acids: metabolism, functions, and nutrition
Guoyao Wu
Amino Acids, 37(1), 1-17 (2009)
Metabolite Profiling Identifies a Key Role for Glycine in Rapid Cancer Cell Proliferation
Mohit Jain
Science, 336(6084), 1040-1044 (2012)
Alexander Carvajal-González et al.
Brain : a journal of neurology, 137(Pt 8), 2178-2192 (2014-06-22)
The clinical associations of glycine receptor antibodies have not yet been described fully. We identified prospectively 52 antibody-positive patients and collated their clinical features, investigations and immunotherapy responses. Serum glycine receptor antibody endpoint titres ranged from 1:20 to 1:60 000.

Questions

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  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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