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Merck
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主要文件

MAB3318

Sigma-Aldrich

抗-TIMP-3抗体(克隆136-13H4)

clone 136-13H4, Chemicon®, from mouse

别名:

Tissue Inhibitor of Metalloproteinase-3

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About This Item

分類程式碼代碼:
12352203
eCl@ss:
32160702
NACRES:
NA.41

生物源

mouse

品質等級

抗體表格

purified immunoglobulin

抗體產品種類

primary antibodies

無性繁殖

136-13H4, monoclonal

物種活性

rabbit, human

製造商/商標名

Chemicon®

技術

immunohistochemistry: suitable (paraffin)
western blot: suitable

同型

IgG1κ

NCBI登錄號

UniProt登錄號

運輸包裝

dry ice

目標翻譯後修改

unmodified

基因資訊

human ... TIMP3(7078)

特異性

与人TIMP-3发生特异性反应。 这是人组织抑制剂金属蛋白酶3(人TIMP-3)上的SWYRGWAPPDKSIINATDP的寡肽(残基170-188)的纯化鼠单克隆抗体。
MAB3318 与TIMP-3发生交叉反应,但是不与人TIMP-1 和人TIMP-2反应。

免疫原

人组织抑制剂金属蛋白酶3上的SWYRGWAPPDKSIINATDP的寡肽(残基170-188)
表位:a.a.170-188

應用

免疫印迹:2 ug/mL

免疫组织化学(石蜡):10ug/mL

免疫组织化学(冷冻):2 ug/mL
抗-TIMP-3 抗体(a.a. 170-188,克隆136-13H4)是一种针对TIMP-3的抗体,可用于 IH(P) & WB。
研究子类别
MMPs & TIMPs
研究类别
细胞结构

標靶描述

26kda

外觀

形式:纯化
液体溶于0.1 M磷酸钠缓冲液,pH值7.0,含有2%无蛋白酶的牛血清白蛋白。
纯化蛋白A

儲存和穩定性

自收到之日起在-20°C可稳定保存1年。避免反复冻融。为了最大程度地回收产品,在融化后和取下盖子之前,将原始小瓶进行离心。

分析報告

对照
乳腺癌组织

其他說明

浓度:请参考批次特异性浓缩物的检验报告。

法律資訊

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

免責聲明

由Daiichi Fine Chemical Co., Ltd生产

除非我们的产品目录或产品附带的其他公司文档另有说明,否则我们的产品仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

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儲存類別代碼

12 - Non Combustible Liquids

水污染物質分類(WGK)

WGK 2

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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访问文档库

Lluis Catasus et al.
Histopathology, 62(4), 632-641 (2013-02-06)
Expression of tissue inhibitor of metalloproteinases-3 (TIMP-3) has been found to be decreased in several types of cancer by promoter gene hypermethylation. However, little is known regarding the silencing effect of TIMP3 promoter hypermethylation on gene and protein expression in
Chun-Wen Su et al.
Cell death & disease, 10(11), 793-793 (2019-10-19)
The tissue inhibitor of metalloproteinase-3 (TIMP3) is the only member of the TIMP family that binds to the extracellular matrix and suppresses cancer cell growth, angiogenesis, migration, and invasion. However, whether the abnormal expression and promoter methylation of TIMP3 facilitates
Qinglei Li et al.
Reproduction (Cambridge, England), 128(5), 555-564 (2004-10-29)
The matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) are potential regulators of the focalized extracellular matrix degradation required for ovulation. The objectives of the present study were to determine localization and temporal regulation of TIMP-3 and TIMP-4 mRNA and
S Jane Darnton et al.
International journal of cancer, 115(3), 351-358 (2005-02-03)
Amongst involvement in diverse physiological and pathological processes, TIMP-3 may have an important role in tumour development, growth and metastasis by interaction with metalloproteases in the extracellular matrix. We studied the role and prognostic effect of TIMP-3 in esophageal adenocarcinoma
Bartlomiej Perek et al.
BioMed research international, 2013, 730721-730721 (2013-10-24)
Migration of the smooth muscle cells (SMCs) to the tunica media in the saphenous vein (SV) transplants is facilitated by matrix metalloproteinases (MMPs). The aim of this study was to identify any associations between expression of MMP-2 or endogenous tissue

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