推荐产品
生物源
mouse
品質等級
抗體表格
purified antibody
抗體產品種類
primary antibodies
無性繁殖
TA205, monoclonal
物種活性
rabbit, human
應無反應活性
mouse, rat
製造商／商標名
Chemicon®
技術
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable
同型
IgG1
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
目標翻譯後修改
unmodified
基因資訊
human ... TLN1(7094)
特異性
Human Talin. This antibody reacts with an N-terminal epitope in talin, between amino acids 139-433. On microinjection into whole cells MAB1676 disrupts actin stress fibers and focal contacts and inhibits cell motility.
免疫原
Epitope: N-terminus, a.a. 139-433
應用
Anti-Talin 1 Antibody, N-terminus, a.a. 139-433, clone TA205 detects level of Talin & has been published & validated for use in IP, WB, IH.
Immunoblotting, recognizes a band at ~230kDa.
Immunoprecipitation
Immunofluorescence
Optimal working dilutions must be determined by end user.
Immunoprecipitation
Immunofluorescence
Optimal working dilutions must be determined by end user.
外觀
Format: Purified
Liquid in 0.02 M PB pH 7.6, 0.25 M NaCl containing 0.1% sodium azide.
儲存和穩定性
Maintain between 2 and 8°C for up to six months.
其他說明
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
法律資訊
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Karen P Fong et al.
Blood advances, 5(23), 4901-4909 (2021-09-28)
Blood clot contraction is driven by traction forces generated by the platelet cytoskeleton that are transmitted to fibrin fibers via the integrin αIIbβ3. Here we show that clot contraction is impaired by inhibitors of the platelet cytosolic protease calpain. We
Karen P Fong et al.
Cellular microbiology, 8(11), 1753-1767 (2006-07-11)
Actinobacillus actinomycetemcomitans produces a leukotoxin (Ltx) that kills leukocyte function-associated antigen-1 (LFA-1)-bearing cells from man, the Great Apes and Old World monkeys. The unique specificity of Ltx for the beta2 integrin, LFA-1, suggests it is capable of providing insight into
Masaru Niki et al.
Thrombosis and haemostasis, 115(5), 969-978 (2016-01-23)
Adaptor proteins play a critical role in the assembly of signalling complexes after engagement of platelet receptors by agonists such as collagen, ADP and thrombin. Recently, using proteomics, the Dok (downstream of tyrosine kinase) adapter proteins were identified in human
Maria Salmela et al.
Scientific reports, 7(1), 3414-3414 (2017-06-15)
Conformational activation of integrins is generally required for ligand binding and cellular signalling. However, we have previously reported that the nonactivated conformation of α2β1 integrin can also bind to large ligands, such as human echovirus 1. In this study, we
Daniel Friedman et al.
Journal of cell science, 134(7) (2021-03-14)
Natural killer (NK) cells can kill infected or transformed cells via a lytic immune synapse. Diseased cells may exhibit altered mechanical properties but how this impacts NK cell responsiveness is unknown. We report that human NK cells were stimulated more
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