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Merck
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Key Documents

662141

Sigma-Aldrich

PR-619

≥99% (HPLC), solid, DUB inhibitor, Calbiochem®

别名:

DUB抑制剂V，PR-619, UCH-L3抑制剂II，UCH-L5/UCH37抑制剂III，USP5抑制剂II，USP7抑制剂I，USP9X抑制剂II，USP14抑制剂IV，USP14抑制剂IV，USP47抑制剂I，2,6-二氨基吡啶-3,5-双（硫氰酸盐），3,5-二硫氰基吡啶-2,6-二胺，PR619，UC

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About This Item

经验公式（希尔记法）:
C7H5N5S2
分子量:
223.28
分類程式碼代碼:
12352200
NACRES:
NA.77

product name

DUB抑制剂V，PR-619, The DUB Inhibitor V, PR-619 controls the biological activity of DUB. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

品質等級

100

化驗

≥99% (HPLC)

形狀

solid

製造商／商標名

Calbiochem®

儲存條件

OK to freeze
protect from light

顏色

light beige to yellow

溶解度

DMSO: 50 mg/mL

運輸包裝

ambient

儲存溫度

2-8°C

一般說明

一种细胞渗透性吡啶胺类广谱DUB抑制剂，其已知靶标包括ATXN3、BAP1、JOSD2、OTUD5、UCH-L1、UCH-L3、UCH-L5/UCH37、USP1、2、4、5、7、8、9X、10、14、15、16、19、20、22、24、28、47、48、VCIP135、YOD1，以及deISGylase PLpro、deNEDDylase DEN1和deSUMOlyase SENP6。PR-619和P22077（目录号662142）均显示以剂量和时间依赖性方式（20至150 µM；0.5至20 h）增加HEK293T细胞中的整体蛋白多聚泛素化，然而P22077暴露主要导致K48连接的富集，而PR619处理导致K48和K63连接的多聚亚基链的上调。

包裝

用惰性气体包装

警告

毒性：标准处理（A）

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

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