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Merck
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文件

662105

Sigma-Aldrich

泛素E1抑制剂，PYR-41

The Ubiquitin E1 Inhibitor, PYR-41 controls the biological activity of Ubiquitin E1. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

别名:

泛素E1抑制剂，PYR-41, 4-(4-(5-硝基-呋喃-2-基亚甲基)-3,5-二氧代-吡唑烷-1-基)-苯甲酸乙酯，三水合物，泛素活化酶E1抑制剂，PYR-41

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About This Item

经验公式（希尔记法）:
C17H13N3O7 · 3H2O
分子量:
425.35
分類程式碼代碼:
12352200
NACRES:
NA.77

品質等級

100

化驗

≥90% (sum of two isomers, HPLC)

形狀

solid

製造商／商標名

Calbiochem®

儲存條件

OK to freeze
protect from light

顏色

dark purple

溶解度

DMSO: 10 mg/mL

運輸包裝

wet ice

儲存溫度

−20°C

一般說明

一种细胞渗透性吡唑酮化合物，不可逆地（可能通过共价修饰）抑制泛素激活酶E1活性（无细胞E1泛素化反应中的IC50<10 µM），同时对E3、E2或半胱天冬酶活性表现出很少或没有活性。阻断泛素化依赖的蛋白质降解和其他泛素化介导的细胞活动。已显示，通过PYR-41或其他方式使E1失活可导致苏素化的总体升高。

包裝

用惰性气体包装

警告

毒性：刺激性（B）

重構

复溶后，等分并冷冻保存（-20°C）。贮备溶液在-20°C下可稳定保存至多1个月。在室温下，化合物每天将经历约1%的分解。

其他說明

Yang, Y., et al. 2007.Cancer Res.67, 9472.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 1

閃點（°F）

Not applicable

閃點（°C）

Not applicable

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Subhash Mehto et al.
The EMBO journal, 41(23), e111289-e111289 (2022-10-13)
The NOD1/2-RIPK2 is a key cytosolic signaling complex that activates NF-κB pro-inflammatory response against invading pathogens. However, uncontrolled NF-κB signaling can cause tissue damage leading to chronic diseases. The mechanisms by which the NODs-RIPK2-NF-κB innate immune axis is activated and

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