5.05277

GTS-21 Dihydrochloride (DMBX-A)

• 别名: GTS-21 Dihydrochloride (DMBX-A), E)-3-(2,4-dimethoxybenzylidene)-3,4,5,6-tetrahydro-2,3ʹ-bipyridine, DMBX-A, α7 nAChR Agonist, GTS-21, Alpha 7 Nicotinic Acetylcholine Receptor Agonist, GTS-21
• 经验公式（希尔记法）: C₁₉H₂₀N₂O₂ · 2HCl
• CAS号: 156223-05-1
• 分子量: 381.30
• MDL號碼: MFCD00941364
• 分類程式碼代碼: 12352200
• NACRES: NA.77

属性

• 化驗: ≥98% (HPLC)
• 品質等級: 100
• 形狀: solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; protect from light
• 顏色: yellow
• 溶解度: DMSO: 100 mM; H₂O: 100 mM
• 儲存溫度: −20°C
• SMILES 字串: [Cl-].[Cl-].n1cc(ccc1)C2=NCCC\C\2=C/c3c(cc(cc3)OC)OC.[H+].[H+]
• InChI: 1S/C19H20N2O2.2ClH/c1-22-17-8-7-14(18(12-17)23-2)11-15-5-4-10-21-19(15)16-6-3-9-20-13-16;;/h3,6-9,11-13H,4-5,10H2,1-2H3;2*1H/b15-11+;;
• InChI 密鑰: BXKYFUGAAFLYJL-BXGYHSFXSA-N

说明

一般說明

A partial agonist selective for α7 nAChRs (EC₅₀ = 10 µM). Used in neuroimmunology studies, cardiovascular disease research, and Alzheimer′s disease studies.

生化／生理作用

Primary Target
α7 nAChR

Reversible: yes

警告

Toxicity: Standard Handling (A)

重構

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他說明

Kox, M., et al. 2011. Br. J. Anaesth.107, 559.
Kox, M., et al., 2011. Shock.36, 5.
Rosas-Ballina, M., et al. 2009. Mol. Med.15, 195.
Briggs, A., et al. 1997. Pharmacol. Biochem. Behav.57, 231.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable