407625

STAT3 Inhibitor XVI

The STAT3 Inhibitor XVI controls the biological activity of STAT3. This small molecule/inhibitor is primarily used for Cancer applications.

• 别名: STAT3 Inhibitor XVI, IL-6 Inhibitor
• 经验公式（希尔记法）: C₂₁H₂₂N₂O₃S₃
• CAS号: 1260364-43-9
• 分子量: 446.61
• MDL號碼: MFCD32671868
• 分類程式碼代碼: 12352200
• NACRES: NA.77

属性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; protect from light
• 顏色: gray
• 溶解度: DMSO: 50 mg/mL, light pink-purple
• 運輸包裝: ambient
• 儲存溫度: 2-8°C
• SMILES 字串: O=C(NCC1=CC=CS1)C2=CC(S(N3CCCC3)(=O)=O)=C(C4=CC=C(C)C=C4)S2

说明

一般說明

A cell-permeable, arylsulphonamidyl thiophene amide that is shown to reduce IL-6-induced STAT3 transcriptional activity (EC₅₀ = 15 µM) in a luciferase reporter assay, in HeLa cells. It selectively inhibits STAT3, but not STAT1, phosphorylation following IL-6 stimulation in both HeLa and MDA-MB-231 breast cancer cells at concentrations of 10-30 &micro:M and 30-100 µM, respectively. Following IL-6 stimulation, it suppresses the cell viability of STAT3-dependent cancer cells by 40% compared with that of STAT3-null cancer cells at the low micromolar level.

包裝

Packaged under inert gas

警告

Toxicity: Regulatory Review (Z)

重構

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他說明

Zinzalla, G., et al. 2010. Bioorg Med Chem Lett20, 7029.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 2
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable