推荐产品
product name
脱氧酪氨酸合成酶抑制剂，GC7, The Deoxyhypusine Synthase Inhibitor, GC7, also referenced under CAS 150333-69-0, controls the biological activity of Deoxyhypusine Synthase.
品質等級
化驗
>95% (NMR)
形狀
powder
製造商／商標名
Calbiochem®
儲存條件
OK to freeze
desiccated (hygroscopic)
顏色
white
溶解度
water: 25 mg/mL, clear, colorless
運輸包裝
ambient
儲存溫度
−20°C
InChI
1S/C8H20N4/c9-6-4-2-1-3-5-7-12-8(10)11/h1-7,9H2,(H4,10,11,12)
InChI 密鑰
YAOAMZOGXBMLFQ-UHFFFAOYSA-N
一般說明
一种细胞渗透性抑制剂，靶向脱氧辅蛋白合酶（Ki=9.7 nM）的亚精胺结合位点，该酶负责真核生物起始因子5A（eIF5A）的第一步hypunisation。在体内，它表明在≥1µ M时CHO细胞中几乎完全停止了腐胺赖氨酸的形成。多项研究表明，该化合物是下调eIF5A（细胞增殖必不可少的蛋白）的有用工具。例如，它在5 µM至40 µM的浓度下对BCR-ABL阳性和阴性白血病系（K562和HL-60）均表现出剂量依赖性的抗增殖效应。此外，它显示出在10-20 µM范围内显着损害原代HCC细胞（HepG2和Hep3B）的生长和侵袭，并且在浓度高达40 µM时对非致瘤性CL-48细胞没有明显的细胞毒性。在25 µM时，显示GC7治疗可逆转eIF5A介导的骨骼肌干细胞分化。
警告
毒性：标准处理（A）
重構
复溶后，等分并冷冻保存（-20°C）。储备溶液在-20°C下可稳定保存至多3个月。
其他說明
Lee, N.P., et al. 2010.Int J Cancer.4, 968.
Luchessi, A., et al. 2008.J Cell Physiol.3, 480.
Balabanov, S., et al. 2007.Blood.4, 1701.
Jakus, J., et al. 1993.J Biol Chem.18, 13151.
Luchessi, A., et al. 2008.J Cell Physiol.3, 480.
Balabanov, S., et al. 2007.Blood.4, 1701.
Jakus, J., et al. 1993.J Biol Chem.18, 13151.
法律資訊
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Rocío Seoane et al.
Frontiers in cellular and infection microbiology, 12, 960138-960138 (2022-08-16)
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