178494

Apoptosis Inhibitor II, NS3694

The Apoptosis Inhibitor II, NS3694, also referenced under CAS 426834-38-0, controls the biological activity of Apoptosis. This small molecule/inhibitor is primarily used for Cancer applications.

• 别名: Apoptosis Inhibitor II, NS3694, NS3694
• 经验公式（希尔记法）: C₁₅H₁₀ClF₃N₂O₃
• CAS号: 426834-38-0
• 分子量: 358.70
• MDL號碼: MFCD00249000
• 分類程式碼代碼: 12352200
• NACRES: NA.77

属性

• 品質等級: 100
• 化驗: ≥95% (HPLC)
• 形狀: solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; protect from light
• 顏色: white
• 溶解度: DMSO: 10 mg/mL; ethanol: slightly soluble
• 運輸包裝: ambient
• 儲存溫度: 2-8°C
• InChI: 1S/C15H10ClF3N2O3/c16-9-4-5-11(13(22)23)12(7-9)21-14(24)20-10-3-1-2-8(6-10)15(17,18)19/h1-7H,(H,22,23)(H2,20,21,24)
• InChI 密鑰: GNCZTZCPXFDPLI-UHFFFAOYSA-N

说明

一般說明

A cell-permeable diarylurea compound that specifically prevents the active ~700-kDa apoptosome complex formation triggered by cytochrome c release, thus blocking apoptosome-mediated caspase activation and cell death (50 µM completely blocks TNF-α-induced death in MCF-casp3 cells). Unlike M50054 (Cat. No. 178488), NS3694 exhibits no effect on apoptosome-independent caspase activation and cell death induced by FasL. Inhibits neither cytochrome c release nor the enzymatic activity of caspases.

A cell-permeable diarylurea compound that specifically prevents the formation of the active ~700 kDa apoptosome complex induced by cytochrome c release. Alters cytochrome c and ATP-triggered association between Apaf-1 and caspase-9. Protects against apoptosome-mediated caspase activation and cell death (50 µM completely blocks TNF-α-induced death in MCF-casp3 cells). Unlike M50054 (Cat. No. 178488), NS3694 exhibits no effect on apoptosome-independent caspase activation and cell death induced by Fas ligand (FasL). Does not inhibit cytochrome c release or the activity of caspase-3 and -9.

生化／生理作用

Cell permeable: yes

Primary Target
Apoptosome complex formation

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 50 µM completely blocks TNF-α-induced death in MCF-casp3 cells

警告

Toxicity: Standard Handling (A)

其他說明

Lademann, U., et al. 2003. Mol. Cell. Biol.23, 7829.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable