推荐产品
生物源
rabbit
品質等級
共軛
ALEXA FLUOR™ 488
抗體表格
purified antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
物種活性
human
物種活性（以同源性預測）
chicken (based on 100% sequence homology), rat (based on 100% sequence homology), mouse (based on 100% sequence homology)
濃度
0.5 mg/mL
技術
immunocytochemistry: suitable
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
目標翻譯後修改
trimethylation (Lys9)
基因資訊
human ... H3C1(8350)
mouse ... H3C1(360198)
rat ... H3C1(679994)
一般說明
Histone H3 is one of the five main histone proteins involved in the structure of chromatin in eukaryotic cells. Featuring a main globular domain and a long N-terminal tail, H3 is involved with the structure of the nucleosomes of the ′beads on a string′ structure. Histone proteins are highly post-translationally modified, and Histone H3 is the most extensively modified of the five histones. Histone H3 sequence variants and variable modification states are thought to play a role in the dynamic and long term regulation of genes. Di- and tri-methylation of histone H3 are gene silencing marks, while removal of these marks by the demethylase genes Jmjd1a and Jmjd2c leads to gene activation. This product is a conjugated version of Cat. No. 07-442.
免疫原
Linear peptide corresponding to Histone H3 trimethylated at Lys9.
應用
Research Category
Epigenetics & Nuclear Function
Epigenetics & Nuclear Function
Research Sub Category
Histones
Histones
This Anti-trimethyl Histone H3 (Lys9) Antibody, Alexa Fluor™ 488 Conjugate is validated for use in ICC for the detection of trimethyl Histone H3 (Lys9).
品質
Evaluated by Immunocytochemistry in HeLa cell lysate.
Immunocytochemistry Analysis: A 1:100 dilution of this antibody detected trimethyl Histone H3 (Lys9) in HeLa cells.
Alexa Fluor™ is a registered trademark of Life Technologies.
Immunocytochemistry Analysis: A 1:100 dilution of this antibody detected trimethyl Histone H3 (Lys9) in HeLa cells.
Alexa Fluor™ is a registered trademark of Life Technologies.
標靶描述
~17 kDa observed (Refer to Cat. No. 07-442)
外觀
Protein A purified
Purified rabbit conjugate in buffer containing PBS with 15 mg/ml BSA and 0.1% Sodium Azide.
儲存和穩定性
Stable for 1 year at 2-8°C from date of receipt.
法律資訊
ALEXA FLUOR is a trademark of Life Technologies
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
12 - Non Combustible Liquids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Gayani Batugedara et al.
Microbial genomics, 6(2) (2020-02-06)
Proteins interacting with DNA are fundamental for mediating processes such as gene expression, DNA replication and maintenance of genome integrity. Accumulating evidence suggests that the chromatin of apicomplexan parasites, such as Plasmodium falciparum, is highly organized, and this structure provides
Maegan L Capitano et al.
The Journal of clinical investigation, 129(6), 2555-2570 (2019-05-21)
The nuclear protein DEK is an endogenous DNA-binding chromatin factor regulating hematopoiesis. DEK is one of only 2 known secreted nuclear chromatin factors, but whether and how extracellular DEK regulates hematopoiesis is not known. We demonstrated that extracellular DEK greatly
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