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品質等級
化驗
≥97% (HPLC)
形狀
lyophilized solid
製造商／商標名
Calbiochem®
儲存條件
OK to freeze
desiccated (hygroscopic)
顏色
white to off-white
溶解度
5% acetic acid: 1 mg/mL
運輸包裝
ambient
儲存溫度
−20°C
InChI
1S/C50H73N15O11/c51-32(16-7-21-56-49(52)53)45(72)65-25-11-20-39(65)47(74)64-24-9-18-37(64)43(70)58-28-40(67)59-34(26-30-12-3-1-4-13-30)41(68)62-36(29-66)46(73)63-23-10-19-38(63)44(71)61-35(27-31-14-5-2-6-15-31)42(69)60-33(48(75)76)17-8-22-57-50(54)55/h1-6,12-15,32-39,66H,7-11,16-29,51H2,(H,58,70)(H,59,67)(H,60,69)(H,61,71)(H,62,68)(H,75,76)(H4,52,53,56)(H4,54,55,57)/t32-,33-,34-,35-,36-,37-,38-,39-/m0/s1
InChI 密鑰
QXZGBUJJYSLZLT-FDISYFBBSA-N
一般說明
Bradykinin, a nonapeptide, is produced in plasma under inflammatory conditions by cleavage of kininogen by kallikrein. Bradykinin is involved in a number of physiological functions, including the release of nitric oxide, stimulation of pain receptors, induction of antimitogenic effects, inhibition of cAMP accumulation, induction of smooth muscle contraction, and vasodilation, as well as in inflammation processes. Also involved in edema resulting from trauma or injury. Improves post-ischemic recovery of the heart via a nitric oxide-dependent mechanism.
應用
Bradykininhas been used in studying the changes in colonic afferent response tobradykinin.
生化／生理作用
Cell permeable: no
Primary Target
Induces the release of nitric oxide
Induces the release of nitric oxide
Product does not compete with ATP.
Reversible: no
包裝
Yes
序列
H-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH
外觀
Supplied as an acetate salt.
重構
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
其他說明
Mombouli, J.V., and Vanhoutte, P.M. 1995. Am. J. Hypertens.8, 195.
Zhu, P., et al. 1995. Cardiovasc. Res.29, 658.
Bedarida, G.V., et al. 1994. Horm. Metab. Res. 26, 109.
Altiok, N., and Fredholm, B.B. 1993. Cell Signal. 5, 279.
Zhu, P., et al. 1995. Cardiovasc. Res.29, 658.
Bedarida, G.V., et al. 1994. Horm. Metab. Res. 26, 109.
Altiok, N., and Fredholm, B.B. 1993. Cell Signal. 5, 279.
法律資訊
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
KV7 but not dual small and intermediate KCa channel openers inhibit the activation of colonic afferents by noxious stimuli
Charity N. Bhebhe, et al.
American Journal of Physiology: Gastrointestinal and Liver Physiology, 325(5), G436-G445 (2023)
Immune System, Pain and Analgesia
H.L. Rittner, et al.
Journal of Separation Science, 5, 407-427 (2008)
Ch Golias et al.
Hippokratia, 11(3), 124-128 (2007-07-01)
The present review article regarding the kinin system-bradykinin is dealing with the biological effects of the abovementioned entity mediated by specific B1 and B2 receptors as well as with its clinical implications known nowadays. The activation of the kinin system-bradykinin
Charity N Bhebhe et al.
American journal of physiology. Gastrointestinal and liver physiology, 325(5), G436-G445 (2023-09-05)
In numerous subtypes of central and peripheral neurons, small and intermediate conductance Ca2+-activated K+ (SK and IK, respectively) channels are important regulators of neuronal excitability. Transcripts encoding SK channel subunits, as well as the closely related IK subunit, are coexpressed
Kwun Nok Mimi Man et al.
eLife, 12 (2023-06-20)
The cellular mechanisms mediating norepinephrine (NE) functions in brain to result in behaviors are unknown. We identified the L-type Ca2+ channel (LTCC) CaV1.2 as a principal target for Gq-coupled α1-adrenergic receptors (ARs). α1AR signaling increased LTCC activity in hippocampal neurons.
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