810184P
Avanti
TopFluor™ PI(4,5)P2
Avanti Research™ - A Croda Brand 810184P, powder
别名:
1-oleoyl-2-{6-[4-(dipyrrometheneboron difluoride)butanoyl]amino}hexanoyl-sn-glycero-3-phosphoinositol-4,5-bisphosphate (ammonium salt)
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所有图片(2)
About This Item
经验公式（希尔记法）:
C50H78BF2N3O20P3
CAS号:
分子量:
1182.89
MDL编号:
UNSPSC代码:
12352211
NACRES:
NA.25
价格与库存信息目前不能提供
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方案
>99% (TLC)
表单
powder
包装
pkg of 1 × 50 μg (with stopper and crimp cap (810184P-50ug))
制造商/商品名称
Avanti Research™ - A Croda Brand 810184P
运输
dry ice
储存温度
−20°C
一般描述
Although PI(4,5)P2 is a minor component of cell membranes, it plays a critical role as a substrate for a number of important signaling proteins. PI(4,5)P2 is an intermediate in the IP3/DAG pathway where it is hydrolyzed by phospholipase C to liberate the second messengers, inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG). PI(4,5)P2 is also a substrate for PI 3-kinase where it is phosphorylated to PI(3,4,5)P3, an activator of downstream signaling components such as the protein kinase AKT.
应用
TopFluor™ PI(4,5)P2 or 1-oleoyl-2-{6-[4-(dipyrrometheneboron difluoride)butanoyl]amino}hexanoyl-sn-glycero-3-phosphoinositol-4,5-bisphosphate (ammonium salt) has been used as a fluorescent lipid in living cells to analyse the cellular localization of phosphatidylinositol (PI)[1] and in the preparation of giant unilamellar vesicles (GUVs) for the ezrin-membrane tethering assays.[2]
包装
2 mL Amber Serum Vial with Stopper and Crimp Cap (810184P-50ug)
法律信息
Avanti Research is a trademark of Avanti Polar Lipids, LLC
TopFluor is a trademark of Avanti Polar Lipids, LLC
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
No data available
闪点(°C)
No data available
Ezrin enrichment on curved membranes requires a specific conformation or interaction with a curvature-sensitive partner
Tsai FC, et al.
eLife, 7, e37262-e37262 (2018)
Feng-Ching Tsai et al.
eLife, 7 (2018-09-21)
One challenge in cell biology is to decipher the biophysical mechanisms governing protein enrichment on curved membranes and the resulting membrane deformation. The ERM protein ezrin is abundant and associated with cellular membranes that are flat, positively or negatively curved.
Probing the subcellular distribution of phosphatidylinositol reveals a surprising lack at the plasma membrane.
James PZ, et al.
The Journal of Cell Biology, 219(3), e201906127-e201906127 (2020)
Xiaojun Shi et al.
Langmuir : the ACS journal of surfaces and colloids, 32(7), 1732-1741 (2016-02-02)
Phosphatidylinositol phosphate (PIP) lipids are critical to many cell signaling pathways, in part by acting as molecular beacons that recruit peripheral membrane proteins to specific locations within the plasma membrane. Understanding the biophysics of PIP-protein interactions is critical to developing
Maria J Sarmento et al.
Langmuir : the ACS journal of surfaces and colloids, 33(43), 12463-12477 (2017-09-30)
Although the evidence for the presence of functionally important nanosized phosphorylated phosphoinositide (PIP)-rich domains within cellular membranes has accumulated, very limited information is available regarding the structural determinants for compartmentalization of these phospholipids. Here, we used a combination of fluorescence
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