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方案
98%
表单
powder
mp
210 °C (dec.) (lit.)
SMILES字符串
Cl.NNc1cccc(c1)[N+]([O-])=O
InChI
1S/C6H7N3O2.ClH/c7-8-5-2-1-3-6(4-5)9(10)11;/h1-4,8H,7H2;1H
InChI key
BKOYKMLGFFASBG-UHFFFAOYSA-N
一般描述
3-Nitrophenylhydrazine (3-NPH) is a derivatizing reagent used for the derivatization of carboxyl- and carbonyl-containing metabolites. This compound is also used as a high-efficiency chemical isotope-labeling reagent. Additionally, 3-nitrophenylhydrazine undergoes a condensation reaction with substituted benzaldehydes resulting in the formation of a series of ten substituted (E)-1-benzylidene-2-(3-nitrophenyl) hydrazine compounds.
应用
<ul>
<li><strong>分析化学中的衍生化剂：</strong>利用LC-MRM-MS技术，将3-硝基苯基肼盐酸盐用作衍生化剂，用于检测感染单纯疱疹病毒1型的生物样品中的γ -羟基丁酸，从而增强法医和临床毒理学的检测能力（Osinaga等人，2022）。</li>
<li><strong>药物配方中的残留分析：</strong>该化合物还可用于氯霉素及其制剂中残留的4-硝基苯甲醛的定量分析，采用3-硝基苯肼衍生化后的高效液相色谱-紫外/可见检测，为保证药品的纯度和安全性提供了可靠的方法（Luo et al., 2018）。</li>
<li><strong>法医在分解分析中的应用：</strong>用于衍生化法医尸检时采集的血液样本（Matoba et al., 2022）。</li>
</ul>
<li><strong>分析化学中的衍生化剂：</strong>利用LC-MRM-MS技术，将3-硝基苯基肼盐酸盐用作衍生化剂，用于检测感染单纯疱疹病毒1型的生物样品中的γ -羟基丁酸，从而增强法医和临床毒理学的检测能力（Osinaga等人，2022）。</li>
<li><strong>药物配方中的残留分析：</strong>该化合物还可用于氯霉素及其制剂中残留的4-硝基苯甲醛的定量分析，采用3-硝基苯肼衍生化后的高效液相色谱-紫外/可见检测，为保证药品的纯度和安全性提供了可靠的方法（Luo et al., 2018）。</li>
<li><strong>法医在分解分析中的应用：</strong>用于衍生化法医尸检时采集的血液样本（Matoba et al., 2022）。</li>
</ul>
警示用语：
Warning
危险分类
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
其他客户在看
Derivatization of N-acyl glycines by 3-nitrophenylhydrazine for targeted metabolomics analysis and their application to the study of diabetes progression in mice
Xiang, Li and Ru, et al.
Analytical Chemistry, 95, 2183-2191 (2023)
François-Xavier Danlos et al.
Cell death & disease, 12(3), 258-258 (2021-03-13)
The circulating metabolome provides a snapshot of the physiological state of the organism responding to pathogenic challenges. Here we report alterations in the plasma metabolome reflecting the clinical presentation of COVID-19 patients with mild (ambulatory) diseases, moderate disease (radiologically confirmed
Lin-Xiu Guo et al.
Molecules (Basel, Switzerland), 25(23) (2020-12-10)
Short-chain fatty acids (SCFAs) are the main microbial fermentation products from dietary fibers in the colon, and it has been speculated that they play a key role in keeping healthy in the whole-body. However, differences in SCFAs concentration in the
Isotope-labeling derivatization with 3-nitrophenylhydrazine for LC/multiple-reaction monitoring-mass-spectrometry-based quantitation of carnitines in dried blood spots
Han, Jun and Higgins, et al.
Analytica Chimica Acta, 1037, 177-187 (2018)
Michele Dei Cas et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1154, 121982-121982 (2020-08-31)
Short and medium fatty acids derived from either dietary sources, gut microbiota, and liver production might play a role in the modulation of metabolism and inflammation. The outcome of different autoimmune or inflammatory diseases could be related to microbiota composition
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