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Merck
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A7300

Sigma-Aldrich

N-乙酰苯醌亚胺

别名:

N-(4-Oxo-1-cyclohexa-2,5-dienylidene)acetamide, N-乙酰基 -对- 苯并醌亚胺, NAPQI

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About This Item

经验公式（希尔记法）:
C8H7NO2
CAS号:
50700-49-7
分子量:
149.15
MDL编号:
MFCD00078909
UNSPSC代码:
12352100
PubChem化学物质编号:
57653880
NACRES:
NA.22

表单

solid

质量水平

100

储存温度

−70°C

SMILES字符串

CC(=O)\N=C1\C=CC(=O)C=C1

InChI

1S/C8H7NO2/c1-6(10)9-7-2-4-8(11)5-3-7/h2-5H,1H3

InChI key

URNSECGXFRDEDC-UHFFFAOYSA-N

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应用

反应物涉及：
  • 氧化还原反应
  • 氢卤化
  • pH 依赖性反应：在酸性介质中，它被水解，在碱性介质中发生羟基化，并在中性 pH 下发生二聚化
  • 对乙酰氨基酚肝毒性的调解
  • 研究确定对乙酰氨基酚治疗自身免疫性疾病的效用

其他说明

对乙酰氨基酚代谢物，可与血清蛋白发生反应。

注意

空气、湿度和光敏感

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000365449
0000320642
0000365449
0000320642
0000250453

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Jeffrey L Woodhead et al.
The Journal of pharmacology and experimental therapeutics, 342(2), 529-540 (2012-05-18)
N-acetylcysteine (NAC) is the treatment of choice for acetaminophen poisoning; standard 72-h oral or 21-h intravenous protocols are most frequently used. There is controversy regarding which protocol is optimal and whether the full treatment course is always necessary. It would
Carmen Flores-Pérez et al.
Biomedical chromatography : BMC, 25(7), 760-766 (2010-09-30)
The aim of the present study was to develop a simple, selective and reliable method to quantify acetaminophen and its toxic metabolite N-acetyl-p-benzoquinoneimine (NAPQI) for pediatric studies using 100 µL plasma samples, by reverse-phase HPLC and UV detection. The assay was
Hannah Simon et al.
Analytical chemistry, 84(20), 8777-8782 (2012-09-14)
During the development of new materials demonstrating biological activity, prediction and identification of reactive intermediates generated in the course of drug metabolism in the human liver is of great importance. We present a rapid and purely instrumental method for the
Xiang Ma et al.
Bioconjugate chemistry, 21(1), 46-55 (2009-12-05)
The purpose of our paper is to develop and validate a fluorescence-based mouse liver microsomal (MLM) assay in screening pharmaceutical reactive metabolites (RMs) using a glutathione (GSH)-conjugated 96-well plate. Poly(2-hydroxyethylmethacrylate) (pHEMA) polymeric membrane was coated on 96-well plates to provide
Cross-linking of protein molecules by the reactive metabolite of acetaminophen, N-acetyl-p-benzoquinone imine, and related quinoid compounds.
A J Streeter et al.
Advances in experimental medicine and biology, 197, 727-737 (1986-01-01)
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