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品質等級
化驗
≥95%
形狀
powder or crystals
顏色
white to off-white
mp
163-164 °C
儲存溫度
−20°C
SMILES 字串
OC(CCC(N1CC2=CC=CC=C2C#CC3=CC=CC=C13)=O)=O
InChI
InChI=1S/C19H15NO3/c21-18(11-12-19(22)23)20-13-16-7-2-1-5-14(16)9-10-15-6-3-4-8-17(15)20/h1-8H,11-13H2,(H,22,23)
應用
DBCO Acid is a bifunctional building block comprising of an acid terminus useful for reaction with amine containing linkers in presence of activators such as EDC or HATU and a dibenzocyclooctyne (DBCO) terminus useful for copper-free click chemistry.
特點和優勢
DBCO compounds react with azides without need of Cu(I) catalyst due to the strained nature of alkyne resulting in formation of fast and stable triazole linkage.
儲存類別代碼
11 - Combustible Solids
水污染物質分類(WGK)
WGK 3
閃點(°F)
Not applicable
閃點(°C)
Not applicable
A stepwise huisgen cycloaddition process: copper(I)-catalyzed regioselective "ligation" of azides and terminal alkynes
Angewandte Chemie (International ed. in English), 41, 2596-2599 (2002)
Copper-free click chemistry in living animals
Proceedings of the National Academy of Sciences of the USA, 107, 1821-1826 (2010)
A stepwise huisgen cycloaddition process: copper(I)-catalyzed regioselective "ligation" of azides and terminal alkynes.
Angewandte Chemie (International ed. in English), 41(14), 2596-2599 (2002-08-31)
Proceedings of the National Academy of Sciences of the United States of America, 107(5), 1821-1826 (2010-01-19)
Chemical reactions that enable selective biomolecule labeling in living organisms offer a means to probe biological processes in vivo. Very few reactions possess the requisite bioorthogonality, and, among these, only the Staudinger ligation between azides and triarylphosphines has been employed
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