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應用
- Chitosan has in the last decades been widely used in a variety of applications, both industrially and pharmaceutically.
- Its positive charges under slightly acidic conditions allow it to form complexes or nanoparticles.
- During the delivery process, the stable compact structure of the complex, with cationic chitosan chains as the outershell and the anionic genes/drugs as the core, efficiently protects genes/drugs from the ″sweeping effect″ of mucociliary clearance and degradation by enzymes.
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Peggy Chan et al.
Biomaterials, 28(3), 540-549 (2006-09-27)
Poor water solubility and low transfection efficiency of chitosan are major drawbacks for its use as a gene delivery carrier. PEGylation can increase its solubility, and folate conjugation may improve gene transfection efficiency due to promoted uptake of folate receptor-bearing
PEGylated chitosan derivatives:Synthesis, characterizations and pharmaceutical applications
Casettarietal L, et al.
Progress in Polymer Science, 37, 659-685 (2012)
Li Xiang et al.
Physical chemistry chemical physics : PCCP, 21(37), 20571-20581 (2019-08-01)
PEGylation can modify the physicochemical properties of native chitosan and improves its water solubility. PEGylated chitosan has been widely used as a gene/drug delivery vector by forming a polyelectrolyte complex (PEC) in biomedical engineering. The molecular interactions of PEGylated chitosan
H Ragelle et al.
Journal of controlled release : official journal of the Controlled Release Society, 176, 54-63 (2014-01-07)
This study aims at developing chitosan-based nanoparticles suitable for an intravenous administration of small interfering RNA (siRNA) able to achieve (i) high gene silencing without cytotoxicity and (ii) stability in biological media including blood. Therefore, the influence of chitosan/tripolyphosphate ratio
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