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909300

Sigma-Aldrich

Carboxylic acid-poly(ethylene glycol)-b-poly(D,L lactide)

PEG average Mn 5,000, PDLA average Mn 16,000

别名:

COOH-PEG-PDLA, COOH-PEG-PLA, Carboxylic acid PEG-PDLA, Carboxylic acid-PEG-PLA

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About This Item

线性分子式:
HO(C3H4O2)m(C2H4O)nC2H3O2
分類程式碼代碼:
12352106
NACRES:
NA.23

形狀

powder or chunks

分子量

PDLA average Mn 16,000 (by NMR)
PEG average Mn 5,000 (by NMR)

顏色

white to tan

儲存溫度

−20°C

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應用

Carboxylic acid-poly(ethylene glycol)-b-poly(D,L lactide) is a functionalized, amphiphilic, diblock copolymer composed of a hydrophilic PEG block and a hydrophobic PLA block. These biodegradable, biocompatible polymers can self-assemble to form nanoparticles, such as micelles and polymersomes, in both aqueous and non-aqueous media. Due to these properties, these polymers are widely used in polymeric nanoparticle formulation to achieve controlled and targeted delivery of therapeutic agents (e.g. APIs, genetic material, peptides, vaccines, and antibiotics). The carboxylic acid functional group on the PEG chain enables rapid and facile surface functionalization, allowing for these materials to be used in applications such as targeted drug delivery.

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

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Ren Zhong Xiao et al.
International journal of nanomedicine, 5, 1057-1065 (2010-12-21)
Due to their small particle size and large and modifiable surface, nanoparticles have unique advantages compared with other drug carriers. As a research focus in recent years, polyethylene glycol-polylactic acid (PEG-PLA) block copolymer and its end-group derivative nanoparticles can enhance
R Gref et al.
Science (New York, N.Y.), 263(5153), 1600-1603 (1994-03-18)
Injectable nanoparticulate carriers have important potential applications such as site-specific drug delivery or medical imaging. Conventional carriers, however, cannot generally be used because they are eliminated by the reticulo-endothelial system within seconds or minutes after intravenous injection. To address these

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