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Merck
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900658

Sigma-Aldrich

甲氧基聚乙二醇-b-聚(L-丙交酯)

5k-5k

别名:

mPEG-b-PLA, mPEG-PLA

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About This Item

线性分子式:
HO[CH(CH3)COO]m[CH2CH2O]nCH3
分類程式碼代碼:
12162002
NACRES:
NA.23

品質等級

100

形狀

solid

儲存溫度

2-8°C

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相关类别

應用

具有生物相容性的两亲嵌段共聚物，由亲水性PEG嵌段和疏水性聚（D,L-丙交酯）（PLA）嵌段组成。这些材料已被用于药物封装和递送应用的控释和纳米颗粒制剂中。可通过控制每个聚合物嵌段的相对长度来制备具有各种属性的定义明确材料。羟基封端可实现对这些材料进行进一步的化学修饰。

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

从最新的版本中选择一种：

分析证书(COA)

Lot/Batch Number
MKCW9384
MKCT1025
MKCP4995
MKCD1641

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Zahra Daman et al.
Pharmaceutical research, 32(11), 3756-3767 (2015-08-01)
Resistance to gemcitabine in pancreatic cancer (PC) may account for the failure of conventional treatments. Recently, salinomycin (SAL) has been identified as selective inhibitor of cancer stem cells (CSCs). In our study, we aimed to deliver SAL to gemcitabine-resistant PC
Ho-Chul Shin et al.
Journal of controlled release : official journal of the Controlled Release Society, 140(3), 294-300 (2009-05-05)
Current clinical and preclinical anticancer formulations are limited by their use of toxic excipients and stability issues upon combining different drug formulations. We have found that poly(ethylene glycol)-block-poly(d,l lactic acid) (PEG-b-PLA) micelles can deliver multiple poorly water-soluble drugs at clinically
Yuan Zhang et al.
Pharmaceutical research, 28(5), 1167-1178 (2011-02-23)
Somatostatin analogue octreotide (OCT)-modified PEG-b-PLA micelles were constructed to bind to somatostatin receptors (SSTRs) overexpressed on tumor cells for enhanced intracellular drug delivery and improved therapeutic efficacy for malignant tumors. Copolymers conjugated with octreotide (OCT-PEG₆₀₀₀-b-PLA₅₀₀₀) were synthesized. The fluorescent probe
Yiguang Wang et al.
Pharmaceutical research, 27(9), 1861-1868 (2010-06-19)
To develop an efficient tumor vasculature-targeted polymeric micelle delivery system for combretastatin A4 (CA4), a novel antivascular agent. CA4-loaded micelles were prepared from poly (ethylene glycol)-b-poly (d, l-lactide) copolymers. RGD peptides that target integrins alphavbeta3 and alphavbeta5, markers of angiogenic

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