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Merck

900656

Sigma-Aldrich

甲氧基聚乙二醇-b-聚(L-丙交酯)

5k-10k

别名:

mPEG-b-PLA, mPEG-PLA, mPEG-PLLA

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About This Item

线性分子式:
HO[CH(CH3)COO]m[CH2CH2O]nCH3
分類程式碼代碼:
12162002
NACRES:
NA.23

應用

Biocompatible, amphiphilic block copolymer composed of a hydrophilic PEG block and a hydrophobic poly(L-lactide) (PLLA) block. These materials have been used in control release and nanoparticle formulation for drug encapsulation and delivery applications. Well-defined materials with varying properties can be prepared by controlling the relative length of each polymer block. Hydroxyl termination allows for facile further chemical modification of these materials.

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

>230.7 °F

閃點(°C)

> 110.4 °C


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Injectable biodegradable polymeric system for preserving the active form and delayed-release of camptothecin anticancer drugs.
Mert O, et al.
Royal Society of Chemistry Advances, 2(1), 176-185 (2012)
Zhigang Xie et al.
Journal of biomedical materials research. Part A, 88(1), 238-245 (2008-02-21)
Docetaxel (DX) is one of the most effective antineoplastic drugs. Its current clinical administration is limited because of its hydrophobicity and serious side effects. A polymer/DX conjugate is designed and successfully prepared to solve these problems. It is monomethoxy-poly(ethylene glycol)-block-poly(L-lactide)/DX

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