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Merck

68255

Sigma-Aldrich

4-甲基-2-氧戊酸

≥98.0% (T)

别名:

2-羰基异己酸, 4-甲基-2-氧基戊酸, α-酮异己酸, 酮亮氨酸

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About This Item

线性分子式:
(CH3)2CHCH2COCOOH
CAS号:
分子量:
130.14
Beilstein:
1701823
EC 号:
MDL编号:
UNSPSC代码:
12352100
PubChem化学物质编号:
NACRES:
NA.22
价格与库存信息目前不能提供

方案

≥98.0% (T)

折射率

n20/D 1.431

沸点

82-83 °C/11 mmHg (lit.)

mp

8-10 °C

密度

1.055 g/mL at 20 °C (lit.)

官能团

carboxylic acid
ketone

储存温度

2-8°C

SMILES字符串

CC(C)CC(=O)C(O)=O

InChI

1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)

InChI key

BKAJNAXTPSGJCU-UHFFFAOYSA-N

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一般描述

4-甲基-2-氧戊酸,又称为α-酮异己酸(KIC),是亮氨酸的代谢产物。[1]常作为合成砌块制备亮氨酸及其衍生物,并可用于胺化反应和不对称合成反应。[2] 另外,KIC还是Strecker醛类形成的中间体。[3]

应用

  • 在人脑酮体代谢中的作用:4-甲基-2-氧戊酸参与创伤性脑损伤患者脑微透析液中酮体代谢的时间模式,说明其在大脑生化通路中的重要作用(Eiden et al., 2019)。

象形图

Corrosion

警示用语:

Danger

危险声明

危险分类

Skin Corr. 1B

储存分类代码

8A - Combustible corrosive hazardous materials

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Lisa S Chow et al.
American journal of physiology. Endocrinology and metabolism, 291(4), E729-E736 (2006-05-18)
Despite being an anabolic hormone in skeletal muscle, insulin's anticatabolic mechanism in humans remains controversial, with contradictory reports showing either stimulation of protein synthesis (PS) or inhibition of protein breakdown (PB) by insulin. Earlier measurements of muscle PS and PB
Intermediate role of ?-keto acids in the formation of Strecker aldehydes
Hidalgo et al.
Basic Food Chemistry, 141, 1140-1146 (2013)
The First Highly Enantioselective Homogeneously Catalyzed Asymmetric Reductive Amination:? Synthesis of ?-N-Benzylamino Acids
Kadyrov et al.
The Journal of Organic Chemistry, 68, 4067-4070 (2003)
Yulan Wang et al.
Proceedings of the National Academy of Sciences of the United States of America, 101(34), 12676-12681 (2004-08-18)
Schistosomiasis, a chronic and debilitating parasitic disease, affects approximately 200 million people in the developing world and imposes a substantial public health and economic impact. Accurately diagnosing at the individual level, monitoring disease progression, and assessing the impact of pharmacological
D L Hachey et al.
Analytical chemistry, 63(9), 919-923 (1991-05-01)
A rapid, single-step procedure for the extraction and derivatization of organic alpha-keto acids from microliter quantities of human plasma has been developed. The keto acids were analyzed as the pentafluorobenzyl (PFB) ester by methane negative chemical ionization gas chromatography/mass spectrometry.

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