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Merck

379115

Sigma-Aldrich

N,N′-二环己基碳二亚胺 溶液

1.0 M in methylene chloride, for peptide synthesis

别名:

DCC

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About This Item

线性分子式:
C6H11N=C=NC6H11
CAS号:
分子量:
206.33
MDL號碼:
分類程式碼代碼:
12352111
PubChem物質ID:
NACRES:
NA.22

product name

N,N′-二环己基碳二亚胺 溶液, 1.0 M in methylene chloride

形狀

liquid

品質等級

反應適用性

reaction type: Coupling Reactions

濃度

1.0 M in methylene chloride

密度

1.247 g/mL at 25 °C

應用

peptide synthesis

SMILES 字串

C1CCC(CC1)N=C=NC2CCCCC2

InChI

1S/C13H22N2/c1-3-7-12(8-4-1)14-11-15-13-9-5-2-6-10-13/h12-13H,1-10H2

InChI 密鑰

QOSSAOTZNIDXMA-UHFFFAOYSA-N

基因資訊

human ... EPHX2(2053)
mouse ... Ephx2(13850)

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應用

DCC( N N ′)-二环己基碳二亚胺)主要用于介导肽偶联 ,也可活化羧酸进行酯化。

訊號詞

Danger

危險分類

Acute Tox. 4 Dermal - Carc. 2 - Eye Dam. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

標靶器官

Central nervous system

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類(WGK)

WGK 3

個人防護裝備

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter


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Liposomes containing alkylated methotrexate analogues for phospholipase A 2 mediated tumor targeted drug delivery.
Kaasgaard T, et al.
Chemistry and Physics of Lipids, 157(2), 94-103 (2009)
Effects of amounts of additives on peptide coupling mediated by a water?soluble carbodiimide in alcohols.
Nozaki S.
The Journal of Peptide Research, 54(2), 162-167 (1999)
Masashi Toei et al.
The Journal of biological chemistry, 288(36), 25717-25726 (2013-07-31)
N,N-Dicyclohexylcarbodiimide (DCCD) is a classical inhibitor of the F0F1-ATP synthase (F0F1), which covalently binds to the highly conserved carboxylic acid of the proteolipid subunit (c subunit) in F0. Although it is well known that DCCD modification of the c subunit
Denys Pogoryelov et al.
Nature chemical biology, 6(12), 891-899 (2010-10-26)
The microscopic mechanism of coupled c-ring rotation and ion translocation in F(1)F(o)-ATP synthases is unknown. Here we present conclusive evidence supporting the notion that the ability of c-rings to rotate within the F(o) complex derives from the interplay between the
Kenji Mizutani et al.
Proceedings of the National Academy of Sciences of the United States of America, 108(33), 13474-13479 (2011-08-05)
The prokaryotic V-ATPase of Enterococcus hirae, closely related to the eukaryotic enzymes, provides a unique opportunity to study the ion-translocation mechanism because it transports Na(+), which can be detected by radioisotope (22Na(+)) experiments and X-ray crystallography. In this study, we

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