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S0520

Sigma-Aldrich

Selenocystamine dihydrochloride

>98% (TLC), suitable for ligand binding assays

Synonyme(s) :

2,2′-diselenobis-Ethanamine hydrochloride (1:2)

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About This Item

Formule empirique (notation de Hill):
C4H12N2Se2 · 2HCl
Numéro CAS:
3542-13-0
Poids moléculaire :
318.99
Numéro MDL:
MFCD00035445
Code UNSPSC :
12352116
ID de substance PubChem :
24899440
Nomenclature NACRES :
NA.26

product name

Selenocystamine dihydrochloride, powder

Pureté

>98% (TLC)

Niveau de qualité

200

Forme

powder

Technique(s)

ligand binding assay: suitable

Couleur

yellow to orange

Solubilité

H2O: soluble, clear to slightly hazy

Chaîne SMILES 

NCC[Se][Se]CCN.[H]Cl.[H]Cl

InChI

1S/C4H12N2Se2.ClH/c5-1-3-7-8-4-2-6;/h1-6H2;1H

Clé InChI

PKRYDZYGNSZBHO-UHFFFAOYSA-N

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Description générale

Selenocystamine dihydrochloride has a potential to block the activity of influenza A and B virus associated RNA-dependent RNA polymerase enzyme.

Application

Selenocystamine dihydrochloride has been used to determine its effect on PP2A phosphatase activity in vitro. It has also been used as a catalyst for a disulfide-cleaving reagent, dithiothreitol (DTT).

Pictogrammes

Skull and crossbonesHealth hazardEnvironment
GHS06,GHS08,GHS09

Mention d'avertissement

Danger

Mentions de danger

H301 + H331,H373,H410

Classification des risques

Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - STOT RE 2

Code de la classe de stockage

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de danger pour l'eau (WGK)

WGK 3

Équipement de protection individuelle

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

M S Stewart et al.
Free radical biology & medicine, 26(1-2), 42-48 (1999-01-16)
The cancer chemopreventive effect of selenium cannot be fully accounted for by the role of selenium as a component of the antioxidant enzyme glutathione peroxidase, which suggests that chemoprevention occurs by another mechanism. Several studies have shown that thiol oxidation
T Tabatabaie et al.
Toxicology and applied pharmacology, 141(2), 389-393 (1996-12-01)
Chronic benzaldehyde exposure is known to cause central nervous system (CNS) disturbances. Previous studies have shown that benzaldehyde causes the formation of reactive oxygen species (ROS) in rat synaptosomal fractions. Benzaldehyde has also been implicated in ROS formation in the
Wansik Cha et al.
Biomaterials, 28(1), 19-27 (2006-09-09)
Novel nitric oxide (NO) generating polymeric materials possessing immobilized organoselenium species are described. These materials mimic the capability of small organoselenium molecules as well as a known selenium-containing enzyme, glutathione peroxidase (GPx), by catalytically decomposing S-nitrosothiols (RSNO) into NO and
L Chen et al.
Free radical biology & medicine, 19(6), 713-724 (1995-12-01)
A selenium (Se)-containing immunoconjugate of a human anti-erythrocyte membrane antibody (Ab-Se) has been synthesized via oxidation of the carbohydrate moieties of the antibody and covalent coupling with selenocystamine. The isolated Ab-Se immunoconjugate is shown to be more hemolytic than is
Axel L Dessal et al.
Molecular pharmacology, 79(1), 24-33 (2010-10-01)
G protein-coupled receptors transduce signals through heterotrimeric G protein Gα and Gβγ subunits, both of which interact with downstream effectors to regulate cell function. Gβγ signaling has been implicated in the pathophysiology of several diseases, suggesting that Gβγ could be
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