M3262

N-Methyl-D-aspartic acid

≥98% (TLC), suitable for cell culture

• Synonyme(s) : (R)-2-(Methylamino)succinic acid, NMDA
• Formule empirique (notation de Hill): C₅H₉NO₄
• Numéro CAS: 6384-92-5
• Poids moléculaire : 147.13
• Numéro Beilstein : 1724431
• Numéro MDL: MFCD00004226
• Code UNSPSC : 12352209
• eCl@ss : 32160406
• ID de substance PubChem : 24277987
• Nomenclature NACRES : NA.32

Propriétés

• product name: N-Methyl-D-aspartic acid, ≥98% (TLC), solid
• Niveau de qualité: 200
• Pureté: ≥98% (TLC)
• Forme: solid
• Technique(s): cell culture | mammalian: suitable
• Couleur: white
• Pf: 189-190 °C
• Application(s): cell analysis
• Chaîne SMILES: CN[C@H](CC(O)=O)C(O)=O
• InChI: 1S/C5H9NO4/c1-6-3(5(9)10)2-4(7)8/h3,6H,2H2,1H3,(H,7,8)(H,9,10)/t3-/m1/s1
• Clé InChI: HOKKHZGPKSLGJE-GSVOUGTGSA-N
• Informations sur le gène: human ... GRIN1(2902) , GRIN2A(2903) , GRIN2B(2904) , GRIN2C(2905) , GRIN2D(2906) , GRINA(2907) ; rat ... Gria1(50592) , Grik1(29559) , Grin2a(24409)

Description

Description générale

N-Methyl-D-aspartic acid (NMDA) is an endogenously generated molecule in rat nervous system and endocrine glands. NMDA is present at low level (nmol/g) in the adenohypophysis, hypothalamus, brain, and testis. NMDA is derived from D-Asp by an S-adenosylmethionine-dependent enzyme also referred to as NMDA synthase.

Application

N-Methyl-D-aspartic acid has been used to induce N-methyl-d-aspartic acid (NMDA) toxicity, cultures of retinal cells were supplemented with NMDA.

Actions biochimiques/physiologiques

Excitotoxic amino acid. Prototypic agonist at the NMDA-type glutamate receptor that regulates ion channels; important in long-term potentiation, ischemia, and epilepsy.

N-Methyl-D-aspartic acid (NMDA) plays a crucial role in release of luteinizing hormone and PRL (prolactin) in the pituitary gland and GnRH (gonadotropin releasing hormone) in the hypothalamus. It acts as a specific agonist for NMDA type glutamate receptors.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)