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R101

Sigma-Aldrich

Ranitidine hydrochloride

solid

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About This Item

Formule empirique (notation de Hill):
C13H22N4O3S · HCl
Numéro CAS:
66357-59-3
Poids moléculaire :
350.86
Numéro CE :
266-333-0
Numéro MDL:
MFCD00069339
Code UNSPSC :
12352200
ID de substance PubChem :
24277803
Nomenclature NACRES :
NA.77

Forme

solid

Niveau de qualité

200

Couleur

tan

Solubilité

H2O: 1.8 mg/mL
45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 7.0 mg/mL

Auteur

GlaxoSmithKline

Chaîne SMILES 

Cl[H].CN\C(NCCSCc1ccc(CN(C)C)o1)=C\[N+]([O-])=O

InChI

1S/C13H22N4O3S.ClH/c1-14-13(9-17(18)19)15-6-7-21-10-12-5-4-11(20-12)8-16(2)3;/h4-5,9,14-15H,6-8,10H2,1-3H3;1H/b13-9-;

Clé InChI

GGWBHVILAJZWKJ-CHHCPSLASA-N

Informations sur le gène

human ... HRH2(3274)

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Application

Ranitidine hydrochloride has been used as a reference compound for the development and validation of parallel artificial membrane permeability assay (PAMPA).

Actions biochimiques/physiologiques

Ranitidine is mainly used to treat gastrointestinal impairment instigated by non-steroidal anti-inflammatory drugs (NSAIDs).
H2 histamine receptor antagonist; anti-ulcer agent.

Caractéristiques et avantages

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictogrammes

Health hazardExclamation mark
GHS08,GHS07

Mention d'avertissement

Danger

Mentions de danger

H315,H317,H319,H334,H335

Classification des risques

Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

Organes cibles

Respiratory system

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

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USP

USP

1467804

Nizatidine

vibrant-m

N1090000

Nizatidine

Cimetidine Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1075

Cimetidine

Ranitidine N-oxide analytical standard

Supelco

69698

Ranitidine N-oxide

Magnesium stearate puriss., meets analytical specification of Ph. Eur., BP, ≥90% stearic and palmitic acid basis, ≥40% stearic acid basis (GC), 4.0-5.0% Mg basis (calc on dry sub.)

Sigma-Aldrich

26454

Magnesium stearate

Enalaprilat analytical standard

Supelco

43301

Enalaprilat

Hydrochlorothiazide crystalline

Sigma-Aldrich

H4759

Hydrochlorothiazide

Triprolidine hydrochloride ≥99%

Sigma-Aldrich

T6764

Triprolidine hydrochloride

Ying Liu et al.
Molecular and cellular biochemistry, 448(1-2), 61-69 (2018-02-07)
Abnormal angiogenesis is critically involved in tumor progression and metastasis including endometrial cancer and is regulated by microRNAs such as microRNA-101 (miR-101). We hypothesize that miR-101 expression is disrupted in endometrial cancer and modulation of miR-101 levels is sufficient to
P W Bliss et al.
Alimentary pharmacology & therapeutics, 13(12), 1669-1674 (1999-12-14)
Gastrin release by Helicobacter pylori may be an important step in the pathway leading to duodenal ulceration. A histamine H3-receptor agonist was found to release gastrin from antral mucosal fragments; this was interpreted as being due to suppression of somatostatin
Ruth Prieto-Montero et al.
Sensors (Basel, Switzerland), 20(19) (2020-10-03)
Functionalized fluorescent silica nanoparticles were designed and synthesized to selectively target cancer cells for bioimaging analysis. The synthesis method and characterization of functionalized fluorescent silica nanoparticles (50-60 nm), as well as internalization and subcellular localization in HeLa cells is reported
Optimization of a parallel artificial membrane permeability assay for the fast and simultaneous prediction of human intestinal absorption and plasma protein binding of drug candidates: application to dibenz [b, f] azepine-5-carboxamide derivatives
Fortuna A, et al.
Journal of Pharmaceutical Sciences, 101(2), 530-540 (2012)
Ranitidine
Grant S M, et al.
Drugs, 37(6), 801-870 (1989)
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