P4543
Valproic acid sodium salt
98%
Synonyme(s) :
2-propylpentanoic Acid Sodium
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About This Item
Formule empirique (notation de Hill):
C8H15NaO2
Numéro CAS:
Poids moléculaire :
166.19
Numéro CE :
Numéro MDL:
Code UNSPSC :
12352106
eCl@ss :
42020819
ID de substance PubChem :
Nomenclature NACRES :
NA.77
Produits recommandés
Niveau de qualité
Pureté
98%
Forme
powder
Solubilité
H2O: 50 mg/mL
Auteur
Abbott
Chaîne SMILES
[Na+].CCCC(CCC)C([O-])=O
InChI
1S/C8H16O2.Na/c1-3-5-7(6-4-2)8(9)10;/h7H,3-6H2,1-2H3,(H,9,10);/q;+1/p-1
Clé InChI
AEQFSUDEHCCHBT-UHFFFAOYSA-M
Informations sur le gène
human ... ALDH5A1(7915)
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Description générale
The antiepileptic effects of Valproic acid (VPA) are achieved by reducing high-frequency neuronal firing through the blockage of voltage-gated sodium, potassium, and calcium channels. This medication affects the biochemical occurrence of aura and impacts pain perception by modulating GABA or glutamate-mediated neurotransmission. Additionally, VPA influences signaling systems such as the Wnt/beta-catenin and ERK pathways, interfering with inositol and arachidonate metabolism. Furthermore, VPA is crucial in expressing multiple genes involved in cell survival, transcription regulation, ion homeostasis, signaltransduction, and cytoskeletal modifications. Both immediate biochemical effects and long-term genomic influences explain the underlying effect of VPA in treating various conditions.
Valproic acid is an anticonvulsant and mood-stabilizing drug. It is used to treat epilepsy and bipolar disorder. Valproic acid helps to repress the Warburg effect and the development of tumor in neuroblastoma.
Valproic acid is an anticonvulsant and mood-stabilizing drug. It is used to treat epilepsy and bipolar disorder. Valproic acid helps to repress the Warburg effect and the development of tumor in neuroblastoma.
Application
Valproic acid sodium salt has been used:
- in resazurin viability assay
- to systematically study its effects of clinical doses on brain volume and offspring behavior
- to study its effect on atherosclerotic lesion size
- in genetic expression studies in mice
Actions biochimiques/physiologiques
Anti-convulsant that also has efficacy as a mood stabilizer in bipolar disorder.
Caractéristiques et avantages
This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Dopamine and Norepinephrine Metabolism page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Produit(s) apparenté(s)
Réf. du produit
Description
Tarif
Mention d'avertissement
Warning
Mentions de danger
Conseils de prudence
Classification des risques
Acute Tox. 4 Oral - Repr. 2
Code de la classe de stockage
11 - Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 3
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Équipement de protection individuelle
dust mask type N95 (US), Eyeshields, Gloves
Certificats d'analyse (COA)
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Les clients ont également consulté
Dose-dependent memory effects and cerebral volume changes after in utero exposure to valproate in the rat
Frisch C H, et al.
Epilepsia, 50(6), 1432-1441 (2009)
Valproic acid suppresses Warburg effect and tumor progression in neuroblastoma
Fang E, et al.
Biochemical and biophysical research communications (2018)
Erik Taubøll et al.
Epilepsia, 50(8), 1868-1874 (2009-06-06)
Recent animal studies have indicated possible reproductive endocrine effects of levetiracetam (LEV). The aim of the present study was to investigate possible reproductive endocrine effects of LEV compared to valproate (VPA) using human ovarian follicular cells. Cell cultures of human
Fetal exposure to valproic acid dysregulates the expression of autism-linked genes in the developing cerebellum
Sette, Claudio et al.
Translational Psychiatry, 1, 114 (2023)-114 (2023) (2023)
Derek Daigle et al.
Journal of virology, 85(11), 5628-5643 (2011-03-18)
Diverse stimuli reactivate the Epstein-Barr virus (EBV) lytic cycle in Burkitt lymphoma (BL) cells. In HH514-16 BL cells, two histone deacetylase (HDAC) inhibitors, sodium butyrate (NaB) and trichostatin A (TSA), and the DNA methyltransferase inhibitor azacytidine (AzaCdR) promote lytic reactivation.
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