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I1146

Sigma-Aldrich

R3 IGF-1 human

recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

Synonyme(s) :

Human IGF-1, IGF-1 Protein, Recombinant IGF-1

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About This Item

Code UNSPSC :
51111800
Nomenclature NACRES :
NA.77

Source biologique

human

Niveau de qualité

200

Produit recombinant

expressed in E. coli

Pureté

≥85% (HPLC)

Forme

lyophilized powder

Puissance

≤10 ng/mL ED50

Qualité

endotoxin tested

Poids mol.

7,676 Da

Conditionnement

pkg of 0.1 mg

Technique(s)

cell culture | mammalian: suitable

Numéro d'accès UniProt

P05019

Température de stockage

2-8°C

Informations sur le gène

human ... IGF1(3479)

Catégories apparentées

Application

R3 IGF-I is a recombinant analog of insulin-like growth factor containing the complete human IGF-I amino acid sequence with substitution of Arg for Glu3. It was developed as an inexpensive, high quality potent analog of IGF for use as a growth factor supplement for serum-free or low serum cell culture.

Recombinantly produced in E. coli using a patented expression system, the peptide is harvested from cells in inclusion bodies, which are dissolved and desalted. The active molecule is properly folded under oxidizing conditions and then purified by several liquid chromatography steps.

Actions biochimiques/physiologiques

Proliferation of chinese hamster ovary CHO cells.

Autres remarques

Recombinant analog of insulin-like growth factor-I with the substitution of Arg for Glu at position 3.

Notes préparatoires

Prepared from 0.1 M acetic acid

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

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Jon Landa et al.
Neurology(R) neuroimmunology & neuroinflammation, 8(1) (2020-11-05)
To describe the clinical syndrome of 4 new patients with seizure-related 6 homolog like 2 antibodies (SEZ6L2-abs), study the antibody characteristics, and evaluate their effects on neuronal cultures. SEZ6L2-abs were initially identified in serum and CSF of a patient with
Yuki Kiyokawa et al.
Journal of clinical medicine, 9(9) (2020-09-06)
Pluripotent stem cells are classified as naïve and primed cells, based on their in vitro growth characteristics and potential to differentiate into various types of cells. Human-induced pluripotent stem cells (iPSCs, also known as epiblast stem cells [EpiSCs]) have limited
Peter Tontonoz et al.
Molecular and cellular biology, 35(7), 1125-1138 (2015-01-22)
We previously showed that the orphan nuclear receptor Nur77 (Nr4a1) plays an important role in the regulation of glucose homeostasis and oxidative metabolism in skeletal muscle. Here, we show using both gain- and loss-of-function models that Nur77 is also a

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