I4657
Insulin-like Growth Factor-I Receptor human
≥95% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder
Synonyme(s) :
IGF-I Receptor
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About This Item
Produits recommandés
Source biologique
human
Niveau de qualité
Produit recombinant
expressed in NSO cells
Essai
≥95% (SDS-PAGE)
Forme
lyophilized powder
Poids mol.
α-chain ~120 & 150 kDa
β subunit ~46 & 50 kDa
Conditionnement
pkg of 50 μg
Impuretés
endotoxin, tested
Numéro d'accès UniProt
Température de stockage
−20°C
Informations sur le gène
human ... IGF1R(3480)
Description générale
IGF1R (insulin-like growth factor I) is a receptor tyrosine kinase. The gene is mapped to human chromosome 15q26. It is expressed in various solid tumors as well as hematologic malignancies.
Application
Insulin-like growth factor-I receptor human has been used to study the binding constants of estradiol to insulin, insulin receptors and insulin-like peptides.
Actions biochimiques/physiologiques
IGF-I receptor, a tyrosine kinase receptor with signal transduction pathways, is comprised of two α and two β subunits. IGF-I receptor binds IGF-I with high affinity, IGF-II with lower affinity, and insulin with weak affinity.
Forme physique
Lyophilized from a 0.2 μm solution in phosphate buffered saline.
Remarque sur l'analyse
As a result of glycosylation in SDS-PAGE under reducing conditions, the recombinant α subunit migrates as a doublet of ~120 kDa and 150 kDa and the β subunit migrates as doublet of ~46 kDa and 50 kDa.
The biological activity is measured by its ability to bind human IGF-I in a functional ELISA assay.
Code de la classe de stockage
11 - Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 3
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Équipement de protection individuelle
Eyeshields, Gloves, type N95 (US)
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Xin Huang et al.
PloS one, 10(7), e0133152-e0133152 (2015-07-15)
Patients with metastatic or recurrent and refractory sarcomas have a dismal prognosis. Therefore, new targeted therapies are urgently needed. This study was designed to evaluate chimeric antigen receptor (CAR) T cells targeting the type I insulin-like growth factor receptor (IGF1R)
Sandra Heskamp et al.
PloS one, 10(2), e0117745-e0117745 (2015-02-14)
The insulin-like growth factor 1 receptor (IGF-1R) may be involved in the development of resistance against conventional cancer treatment. The aim of this study was to assess whether IGF-1R expression of breast tumors changes during neoadjuvant therapy and to study
Jin-Ho Choi et al.
The Journal of clinical endocrinology and metabolism, 96(1), E130-E134 (2010-10-22)
Mutations in the IGF1R gene result in intrauterine growth retardation and postnatal growth failure. The objective of this study was to describe the clinical features of subjects with a mutation in the IGF1R gene and to evaluate the molecular and
Robert Root-Bernstein et al.
Frontiers in endocrinology, 5, 118-118 (2014-08-08)
Insulin (INS) resistance associated with hyperestrogenemias occurs in gestational diabetes mellitus, polycystic ovary syndrome, ovarian hyperstimulation syndrome, estrogen therapies, metabolic syndrome, and obesity. The mechanism by which INS and estrogen interact is unknown. We hypothesize that estrogen binds directly to
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