C1188
Bovine Collagen Type II
from bovine tracheal cartilage, powder
Se connecterpour consulter vos tarifs contractuels et ceux de votre entreprise/organisme
About This Item
Numéro CAS:
Numéro CE :
Numéro MDL:
Code UNSPSC :
12352202
Nomenclature NACRES :
NA.61
Produits recommandés
product name
Collagen from bovine tracheal cartilage, Bornstein and Traub Type II, powder
Source biologique
bovine cartilage (tracheal)
Niveau de qualité
Forme
powder
Solubilité
aqueous acid: soluble
Numéro d'accès UniProt
Température de stockage
2-8°C
Informations sur le gène
cow ... COL2A1(407142)
Description générale
Collagen protein is abundantly present in human. It is the prime structural constituent of dermis. It is also an important constituent of extracellular matrix (ECM).
Collagen is classified into a number of structurally and genetically distinct types. We use the nomenclature proposed by Bornstein and Traub. Do not confuse Sigma type designations with recognized collagen classification types.
Application
Collagen from bovine tracheal cartilage has been used to induce arthritis in male DBA/1 mice. It has also been used as a fluorophore to acquire fluorescence emission spectra on the reflectance and fluorescence lifetime spectrometer (RFLS).
Collagen-type II has been investigated for its importance in haemostasis. Two peptides, CB8 and CB11, are sites of platelet binding and activation on collagen-type II. Collagen-type II has also been used as a model for arthritis in animals, where FR140423, a selective cyclooxygenase (COX)-2 inhibitor, has shown an anti-inflammatory effect without gastric lesions that may occur with treatment via indomethacin.
Collagen Type II is sometimes used to induce an animal model of rheumatoid arthritis. However, under conditions leading to formation of reactive oxygen species, the subjects develop tolerance for auto-antibodies. This is an unusual situation of ROS having a favorable effect.
Collagen Type II is sometimes used to induce an animal model of rheumatoid arthritis. However, under conditions leading to formation of reactive oxygen species, the subjects develop tolerance for auto-antibodies. This is an unusual situation of ROS having a favorable effect.
Actions biochimiques/physiologiques
Collagen participates in the aging process. It offers a structural framework for cells and mechanical strength to tissues.
Notes préparatoires
Prepared by a modification of the pepsin extraction procedure of Trentham, et al., J. Exp. Med., 146, 857 (1977).
Code de la classe de stockage
11 - Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 1
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Équipement de protection individuelle
Eyeshields, Gloves, type N95 (US)
Certificats d'analyse (COA)
Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".
Déjà en possession de ce produit ?
Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.
Les clients ont également consulté
Important role of interleukin-3 in the early phase of collagen-induced arthritis
Bruhl H, et al.
Arthritis and Rheumatism, 60(5), 1352-1361 (2009)
Molecular and cellular basis of hypertrophic scarring
Total Burn Care, 495-505 (2012)
Rosalia Cuahtecontzi Delint et al.
Biomaterials, 276, 120996-120996 (2021-07-20)
One of the major challenges within the emerging field of injectable stem cell therapies for articular cartilage (AC) repair is the retention of sufficient viable cell numbers at the site of injury. Even when delivered via intra-articular injection, the number
Quantitative molecular sensing in biological tissues: an approach to non-invasive optical characterization
Chandra M, et al.
Optics Express, 14(13), 6157-6171 (2006)
Aging and the skin
Brocklehurst's Textbook of Geriatric Medicine and Gerontology, 133-137 (2010)
Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..
Contacter notre Service technique