B7880

8-Bromoadenosine 3′,5′-cyclic monophosphate sodium salt

≥97% (HPLC), powder

• Synonyme(s) : 8-Br-cAMP
• Formule empirique (notation de Hill): C₁₀H₁₀BrN₅NaO₆P
• Numéro CAS: 76939-46-3
• Poids moléculaire : 430.08
• Numéro Beilstein : 7739743
• Numéro MDL: MFCD00005844
• Code UNSPSC : 41106305
• ID de substance PubChem : 24278020
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 200
• Pureté: ≥97% (HPLC)
• Forme: powder
• Couleur: off-white
• Solubilité: H₂O: 100 mg/mL
• Température de stockage: −20°C
• Chaîne SMILES: [Na+].Nc1ncnc2n([C@@H]3O[C@@H]4COP([O-])(=O)O[C@H]4[C@H]3O)c(Br)nc12
• InChI: 1S/C10H11BrN5O6P.Na/c11-10-15-4-7(12)13-2-14-8(4)16(10)9-5(17)6-3(21-9)1-20-23(18,19)22-6;/h2-3,5-6,9,17H,1H2,(H,18,19)(H2,12,13,14);/q;+1/p-1/t3-,5-,6-,9-;/m1./s1
• Clé InChI: DMRMZQATXPQOTP-GWTDSMLYSA-M

Description

Description générale

8-Bromoadenosine 3′:5′-cyclic monophosphate is a brominated cyclic mononucleotide.

Application

8-Bromoadenosine 3′,5′-cyclic monophosphate sodium salt has been used:

• to study its effect on fas and caspase-3 mRNA expression and on P4 production in bovine mid luteal cell culture
• used to treat choriocarcinoma BeWo cell line and study its effect on cell viability, apoptosis and morphological changes in the nuclei
• in superfusion medium for head kidneys stimulation

Actions biochimiques/physiologiques

Cell-permeable cAMP analog having greater resistance to hydrolysis by phosphodiesterases than cAMP. Activates protein kinase A, inhibits growth, decreases proliferation, increases differentiation, and induces apoptosis of cultured cells.

Caractéristiques et avantages

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Autres remarques

Membrane-permeable cAMP analog.

Attention

Sensitive to light and moisture.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)