P7556

Progesterone-Water Soluble

powder, BioReagent, suitable for cell culture

• Synonyme(s) : Progesterone: HBC complex, Progesterone: methyl-β-cyclodextrin complex
• Numéro MDL: MFCD00003658
• Code UNSPSC : 12352209
• ID de substance PubChem : 57654558
• Nomenclature NACRES : NA.77

Propriétés

• Source biologique: synthetic (organic)
• Niveau de qualité: 200
• Gamme de produits: BioReagent
• Forme: powder
• Concentration: ≥65% (HPLC)
• Technique(s): cell culture | mammalian: suitable
• Solubilité: H₂O: 25 mg/mL, clear to slightly hazy
• Conditions d'expédition: ambient
• Température de stockage: room temp
• Chaîne SMILES: [H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])CC[C@]4(C)[C@H](CC[C@@]24[H])C(C)=O
• InChI: 1S/C21H30O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12,16-19H,4-11H2,1-3H3/t16-,17+,18-,19-,20-,21+/m0/s1
• Clé InChI: RJKFOVLPORLFTN-LEKSSAKUSA-N
• Informations sur le gène: human ... ABCB1(5243) , AR(367) , CYP2C9(1559) , EBP(10682) , ESR1(2099) , ESR2(2100) , NR3C1(2908) , NR3C2(4306) , PGR(5241) , SERPINA6(866) ; mouse ... Esr1(13982) ; rat ... Ar(24208) , Nr3c1(24413) , Pgr(25154)

Description

Description générale

Progesterone is a steroid hormone secreted by the ovaries.

Application

Progesterone-Water Soluble has been used:

• for in vitro maturation of oocyte complexes
• as a σ1R antagonist to study its effect on sigma 1 receptor
• to study its effect on the differentiation of human multipotent mesenchymal stromal cells (hMSCs) in vitro

This product is not recommended for use in binding assays.

Actions biochimiques/physiologiques

Progesterone is a hormone that maintains pregnancy. It is essential for embryo formation, development and survival in almost all mammals. This hormone exhibits its action via progesterone receptor, which is specifically expressed in the endometrial stroma throughout pregnancy. It is known to prevent preterm delivery, when administered intramuscularly. Progesterone also controls gonadotropin secretion, activates sexual behavior and triggers ovarian events leading to ovulation. It stimulates the growth and differentiation of the uterus and prevents uterine contractility.

Conditionnement

Package size based on progesterone content

Autres remarques

Contains approx. 70 mg progesterone per gram; balance methyl-β-cyclodextrin.

Informations sur la sécurité

• Pictogrammes: GHS08
• Mention d'avertissement: Danger
• Mentions de danger: H351,H360FD,H362
• Conseils de prudence: P202 - P260 - P263 - P264 - P280 - P308 + P313
• Classification des risques: Carc. 2 - Lact. - Repr. 1A
• Code de la classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable