94072
Phalloidin–Atto 565
suitable for fluorescence, ≥80.0% (HPLC)
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About This Item
Code UNSPSC :
12352108
Nomenclature NACRES :
NA.32
Produits recommandés
Niveau de qualité
Pureté
≥80.0% (HPLC)
Forme
solid
Poids mol.
Mw 1394 g/mol
Fabricant/nom de marque
ATTO-TEC GmbH
λ
in methanol
Absorption UV
λ: 562.0-568.0 nm Amax
Adéquation
suitable for fluorescence
Température de stockage
−20°C
Description générale
Atto 565 is a novel fluorescent label that belongs to the class of Rhodamine dyes. It shows a strong absorption, high fluorescence quantum yield, high thermal and photostability, and a very little triplet formation. Atto 565 consists of a mixture of two isomers with practically identical optical absorption and emission Phalloidin is a fungal toxin isolated from the poisonous mushroom Amanita phalloides. Its toxicity is attributed to the ability to bind F actin in liver and muscle cells. As a result of binding phalloidin, actin filaments become strongly stabilized. Phalloidin has been found to bind only to polymeric and oligomeric forms of actin, and not to monomeric actin. The dissociation constant of the actin-phalloidin complex has been determined to be on the order of 3 x 10-8. Phalloidin differs from amanitin in rapidity of action; at high dose levels, death of mice or rats occurs within 1 or 2 hours. Fluorescent conjugates of phalloidin are used to label actin filaments for histological applications. Some structural features of phalloidin are required for the binding to actin. However, the side chain of amino acid 7 (g-d-dihydroxyleucine) is accessible for chemical modifications without appreciable loss of affinity for actin.
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Code de la classe de stockage
11 - Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 3
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
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