85558

Spermidine

BioUltra, for molecular biology, ≥99.5% (GC)

• Synonyme(s) : SPD, 1,8-Diamino-4-azaoctane, N-(3-Aminopropyl)-1,4-diaminobutane
• Formule linéaire : NH₂(CH₂)₃NH(CH₂)₄NH₂
• Numéro CAS: 124-20-9
• Poids moléculaire : 145.25
• Numéro Beilstein : 1698591
• Numéro CE : 204-689-0
• Numéro MDL: MFCD00008229
• Code UNSPSC : 12352116
• ID de substance PubChem : 57653053
• Nomenclature NACRES : NA.26

Propriétés

• Qualité: for molecular biology
• Niveau de qualité: 200
• Gamme de produits: BioUltra
• Pureté: ≥99.5% (GC)
• Conditions de stockage: (Tightly closed. Keep locked up or in an area accessible only to qualified or authorizedpersons.)
• Technique(s): ChIP: suitable; buffer exchange: suitable
• Impuretés: DNases, none detected; RNases, none detected; insoluble matter, passes filter test; phosphatases, none detected; proteases, none detected
• Indice de réfraction: n20/D 1.479 (lit.)
• pH: 12.0-13.5 (25 °C, 1 M in H₂O)
• Solubilité: H₂O: 1 M at 20 °C, clear, colorless
• Densité: 0.925 g/mL at 25 °C (lit.)
• Traces d'anions: chloride (Cl^-): ≤50 mg/kg; sulfate (SO₄^2-): ≤50 mg/kg
• Traces de cations: Al: ≤5 mg/kg; As: ≤0.1 mg/kg; Ba: ≤5 mg/kg; Bi: ≤5 mg/kg; Ca: ≤10 mg/kg; Cd: ≤5 mg/kg; Co: ≤5 mg/kg; Cr: ≤5 mg/kg; Cu: ≤5 mg/kg; Fe: ≤5 mg/kg; K: ≤50 mg/kg; Li: ≤5 mg/kg; Mg: ≤5 mg/kg; Mn: ≤5 mg/kg; Mo: ≤5 mg/kg; Na: ≤50 mg/kg; Ni: ≤5 mg/kg; Pb: ≤5 mg/kg; Sr: ≤5 mg/kg; Zn: ≤5 mg/kg
• λ: 1 M in H₂O
• Absorption UV: λ: 260 nm A_max: 0.1; λ: 280 nm A_max: 0.05
• Chaîne SMILES: NCCCCNCCCN
• Adéquation: suitable for molecular biology
• Application(s): advanced drug delivery; genomic analysis
• InChI: 1S/C7H19N3/c8-4-1-2-6-10-7-3-5-9/h10H,1-9H2
• Clé InChI: ATHGHQPFGPMSJY-UHFFFAOYSA-N
• Informations sur le gène: rat ... Ppm1a(24666)

Description

Description générale

Spermidine is a polyamine and a trivalent organic cation.Spermidine is a naturally occurring polyamine compound with diverse biochemical properties. It plays a vital role in gene expression, participating in DNA replication, transcription, and translation processes. Spermidine is crucial for cell growth, proliferation, and differentiation, influencing cell cycle progression and tissue development. It possesses antioxidant activity, safeguarding cells against oxidative stress by scavenging free radicals. Spermidine also stimulates autophagy, promoting the turnover of damaged organelles and protein aggregates for cellular homeostasis. With neuroprotective effects, it supports neuronal survival, synaptic plasticity, and guards against neurodegenerative diseases. Additionally, spermidine modulates cellular signaling pathways involved in inflammation and immune responses.

Application

Spermidine has been used:

• as a component of chromosome isolation buffer
• as a component of transcription buffer
• as a component of homogenization buffer

Actions biochimiques/physiologiques

Inhibits neuronal nitric oxide synthase (nNOS). Binds and precipitates DNA; may be used for purification of DNA binding proteins. Stimulates T₄ polynucleotide kinase activity.

Spermidine modulates various cellular activities like cellular growth and development, stability of DNA and apoptosis.

Caractéristiques et avantages

• Versatile and adaptable for a wide variety of laboratory and research applications
• Suitable for Molecular Biology and Biochemical research
• Free from DNase, RNase, NICKase, and protease
• Tested to confirm low levels of heavy metal contamination, ensuring suitability for various applications
• Tested for trace levels of Anions and Cations

Attention

Solutions should be sterile-filtered, not autoclaved, if sterile solution is necessary. Spermidine deaminates with time; solutions should be stored frozen. Prepare new solutions frequently.

Remarque sur l'analyse

liquid or solid

Autres remarques

For additional information on our range of Biochemicals, please complete this form.

In first strand cDNA synthesis; Effect on endonuclease inhibition by agarose contaminants

Informations sur la sécurité

• Pictogrammes: GHS05
• Mention d'avertissement: Danger
• Mentions de danger: H314
• Conseils de prudence: P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 - P363 - P405
• Classification des risques: Eye Dam. 1 - Skin Corr. 1B
• Code de la classe de stockage: 8A - Combustible corrosive hazardous materials
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): 233.6 °F - closed cup
• Point d'éclair (°C): 112 °C - closed cup
• Équipement de protection individuelle: Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter