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D0400000

Deoxycorticosterone acetate

European Pharmacopoeia (EP) Reference Standard

Synonyme(s) :

21-hydroxy-4-pregnène-3,20-dione 21-acétate, 4-Pregnène-21-ol-3,20-dione 21-acétate, Cortexone acétate, DOC acétate

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About This Item

Formule empirique (notation de Hill):
C23H32O4
Numéro CAS:
56-47-3
Poids moléculaire :
372.50
Beilstein:
2570798
Numéro MDL:
MFCD00003660
Code UNSPSC :
41116107
ID de substance PubChem :
329798604
Nomenclature NACRES :
NA.24

Qualité

pharmaceutical primary standard

Famille d'API

desoxycortone

Fabricant/nom de marque

EDQM

Application(s)

pharmaceutical (small molecule)

Format

neat

Chaîne SMILES 

[H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])CC[C@]4(C)[C@]([H])(CC[C@@]24[H])C(=O)COC(C)=O

InChI

1S/C23H32O4/c1-14(24)27-13-21(26)20-7-6-18-17-5-4-15-12-16(25)8-10-22(15,2)19(17)9-11-23(18,20)3/h12,17-20H,4-11,13H2,1-3H3/t17-,18-,19-,20+,22-,23-/m0/s1

Clé InChI

VPGRYOFKCNULNK-ACXQXYJUSA-N

Informations sur le gène

human ... NR3C2(4306)

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Catégories apparentées

Description générale

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Desoxycortone acetate EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Conditionnement

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Autres remarques

Sales restrictions may apply.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Lot/Batch Number

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Carrie A Northcott et al.
Experimental biology and medicine (Maywood, N.J.), 237(1), 99-110 (2012-01-10)
One challenge in understanding the polygenic disease of hypertension is elucidating the genes involved and defining responses to environmental factors. Many studies focus on animal models of hypertension; however, this does not necessarily extrapolate to humans. Current technology and cost
Saad Lahlou et al.
Fundamental & clinical pharmacology, 17(3), 323-330 (2003-06-14)
The present study investigated the hypotensive responses to intravenous (i.v.) treatment with the essential oil of Alpinia zerumbet (EOAZ) and its main constituent, terpinen-4-ol (Trp-4-ol), in the experimental model of deoxycorticosterone-acetate (DOCA)-salt hypertensive rat. In both DOCA-salt hypertensive and uninephrectomized
J P Davis et al.
Clinical science (London, England : 1979), 81(1), 73-78 (1991-07-01)
1. Hypertension was induced in male Sprague-Dawley rats by left unilateral nephrectomy and deoxycorticosterone acetate--salt administration. After 5 weeks, arterial systolic blood pressure was significantly elevated in these animals (191.5 +/- 6.0 mmHg, mean +/- SD, n = 17) compared
Ashok Jadhav et al.
Experimental biology and medicine (Maywood, N.J.), 234(7), 764-778 (2009-05-12)
In hypertension, elevated levels of oxidative/inflammatory mediators including nuclear factor kappaB (NF-kappaB), activating protein (AP-1), c-Jun-NH2-terminal kinase (JNK), and cell-regulatory proteins such as transforming growth factor beta (TGF-beta), trigger the mobilization of extracellular matrix (ECM) leading to fibrosis, hypertrophy and
Riccardo Candido et al.
American journal of hypertension, 18(6), 844-850 (2005-06-01)
The aim of the present study was to compare glomerular permeability alterations associated with experimental hypertension models known to have different effects on the circulating renin-angiotensin system (RAS). Five groups, 10 animals each, were studied. One group served as a
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