422711-M

KN-93, Water-Soluble

This KN-93 is a water-soluble version of KN-93 that acts as a reversible and competitive inhibitor of CaM kinase II (K_i = 370 nM for rat brain).

• Synonyme(s) : KN-93, Water-Soluble
• Formule empirique (notation de Hill): C₂₆H₂₉ClN₂O₄S · xH₃PO₄
• Poids moléculaire : 501.04
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Pureté: ≥95% (HPLC)
• Forme: solid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; desiccated (hygroscopic); protect from light
• Couleur: white
• Solubilité: water: 5 mg/mL
• Température de stockage: 2-8°C

Description

Description générale

Also available as a 5 mM solution in H₂O(Cat. No. 508315).

A water-soluble form of the CaM kinase II inhibitor KN-93 (Cat. No. 422708. Inhibits glucose-induced and forskolin-stimulated insulin release from isolated pancreatic islets of Langerhans. Has no significant effect on protein kinase A activity. Induces G₁ cell cycle arrest and apoptosis in NIH 3T3 cells.

Actions biochimiques/physiologiques

Primary Target
Calmodulin-Dependent Protein Kinase (CaM Kinase) 2

Target K_i: 370 nM for cam kinase 2

Avertissement

Toxicity: Irritant (B)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Autres remarques

Tombes, R.M., et al. 1995. Cell Growth Differ.6, 1063.
Chen, C., et al. 1994. Science266, 291.
Mamiya, N., et al. 1993. Biochem. Biophys. Res. Commun.195, 608.
Nicki, I., et al. 1993. Biochem. Biophys. Res. Commun.191, 255.
Sumi, M., et al. 1991. Biochem. Biophys. Res. Commun.181, 968.
Tokumitsu, H., et al. 1990. J. Biol. Chem.265, 4315.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable