OK to freeze avoid repeated freeze/thaw cycles protect from light
storage temp.
−70°C
General description
A water-soluble form of the CaM kinase II inhibitor KN-93 (Cat. No. 422708). Inhibits glucose-induced and forskolin-stimulated insulin release from isolated pancreatic islets of Langerhans. Has no significant effect on protein kinase A activity. Induces G1 cell cycle arrest and apoptosis in NIH 3T3 cells.
Biochem/physiol Actions
Cell permeable: yes
Primary Target CaM kinase II
Reversible: yes
Packaging
Packaged under inert gas
Warning
Toxicity: Standard Handling (A)
Physical form
A 5 mM (500 µg/167 µL) sterile-filtered solution of KN-93 Phosphate (Cat. No. 422711) in H₂O.
Reconstitution
Following initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C.
Other Notes
Tombes, R.M., et al. 1995. Cell Growth Differ.6, 1063. Chen, C., et al. 1994. Science266, 291. Mamiya, N., et al. 1993. Biochem. Biophys. Res. Commun.195, 608. Nicki, I., et al. 1993. Biochem. Biophys. Res. Commun.191, 255. Sumi, M., et al. 1991. Biochem. Biophys. Res. Commun.181, 968. Tokumitsu, H., et al. 1990. J. Biol. Chem.265, 4315.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class
12 - Non Combustible Liquids
wgk_germany
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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