Copper-promoted sulfenylation of sp2 C-H bonds.

Copper-promoted sulfenylation of sp2 C-H bonds.

Journal of the American Chemical Society (2012-10-30)

Ly Dieu Tran, Ilya Popov, Olafs Daugulis

PMID23102009

ZUSAMMENFASSUNG

An auxiliary-assisted, copper catalyzed or promoted sulfenylation of benzoic acid derivative β-C-H bonds and benzylamine derivative γ-C-H bonds has been developed. The method employs disulfide reagents, copper(II) acetate, and DMSO solvent at 90-130 °C. Application of this methodology to the direct trifluoromethylsulfenylation of C-H bonds was demonstrated.

MATERIALIEN

Produktnummer

Marke

Produktbeschreibung

242381

Sigma-Aldrich

Benzoesäure, ACS reagent, ≥99.5%

W213101

Sigma-Aldrich

Benzoesäure, ≥99.5%, FCC, FG

PHR1050

Supelco

Benzoesäure, Pharmaceutical Secondary Standard; Certified Reference Material

73983

Supelco

Mettler-Toledo Kalibriersubstanz ME 18555, Benzoesäure, analytical standard, (for the calibration of the melting point system), traceable to primary standards (LGC)

109479

Sigma-Aldrich

Benzoesäure, ReagentPlus^®, 99%

76170

Supelco

Schmelzpunktstandard 121-123°C, analytical standard

18102

Sigma-Aldrich

Benzoesäure, meets analytical specification of Ph. Eur., BP, USP, FCC, E210, 99.5-100.5% (alkalimetric)

W213128

Sigma-Aldrich

Benzoesäure, natural, ≥99.5%, FCC, FG