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Merck

T5134

Sigma-Aldrich

(±)-α-Tocopherol nicotinate

Synonym(e):

Vitamin E nicotinate

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About This Item

Empirische Formel (Hill-System):
C35H53NO3
CAS-Nummer:
Molekulargewicht:
535.80
EG-Nummer:
MDL-Nummer:
UNSPSC-Code:
12352211
PubChem Substanz-ID:
NACRES:
NA.79

Assay

≥98%

Qualitätsniveau

Form

solid or liquid

Farbe

white to yellow

Lagertemp.

2-8°C

SMILES String

CC(C)CCC[C@@H](C)CCC[C@@H](C)CCC[C@]1(C)CCc2c(C)c(OC(=O)c3cccnc3)c(C)c(C)c2O1

InChI

1S/C35H53NO3/c1-24(2)13-9-14-25(3)15-10-16-26(4)17-11-20-35(8)21-19-31-29(7)32(27(5)28(6)33(31)39-35)38-34(37)30-18-12-22-36-23-30/h12,18,22-26H,9-11,13-17,19-21H2,1-8H3/t25-,26-,35-/m1/s1

InChIKey

MSCCTZZBYHQMQJ-AZAGJHQNSA-N

Allgemeine Beschreibung

α-Tocopherol nicotinate is a fat soluble vitamin. It is an ester of tocopherol and niacin. Niacin is linked to the hydroxyl group of active vitamin E in this ester. α-Tocopherol is a form of vitamin E, which is available through dietary sources. RRR-α-tocopherol is a natural form of α-Tocopherol.

Anwendung

(±)-α-Tocopherol nicotinate has been used in metabolic studies to assess its biological functions in rats.

Biochem./physiol. Wirkung

α-Tocopherol is a radical-chain breaker owing to its anti-oxidant property.
Tocopherols (TCP) (vitamin E) are a series (α, β, γ and δ) of chiral organic molecules that vary in their degree of methylation of the phenol moiety of the chromanol ring. Tocopherols are lipid soluble anti-oxidants that protect cell membranes from oxidative damage. α-Tocopherol is the form of tocopherol preferentially absorbed by homo sapiens. α-Tocopherol nicotinate is used along the α-Tocopherol acetate, α-Tocopherol succinate and other esterified forms as a vitamin E supplement with similar but differential activities.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)


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Kunden haben sich ebenfalls angesehen

N Inagaki et al.
Journal of pharmacobio-dynamics, 7(1), 70-74 (1984-01-01)
Effect of vitamin E (alpha-tocopheryl acetate and alpha-tocopheryl nicotinate) on IgE antibody formation in mice was investgiated . Female BALB/c mice were immunized with dinitrophenylated ascaris protein (DNP-As) and aluminium hydroxide gel (alum). Supplementation of vitamin E in diets or
Tocopherols, tocotrienols and tocomonoenols: Many similar molecules but only one vitamin E
Azzi A
Redox Biology, 101259-101259 (2019)
[Effects of soysterol, pantethine and dl-alpha-tocopheryl nicotinate on hyperlipemia in rats (author's transl)].
S Nakayama et al.
Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 78(3), 191-202 (1981-09-01)
Mitsuru Nakazawa et al.
Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde, 225(2), 120-126 (2010-10-16)
To assess the effects of nilvadipine on the progression of central visual field defect in retinitis pigmentosa (RP). Prospective, randomized, nonmasked, single-center trial. Patients with RP were randomly divided into a treated group receiving oral nilvadipine at 4 mg/day for
J Hasegawa et al.
International journal of clinical pharmacology, therapy, and toxicology, 19(5), 216-219 (1981-05-01)
The effect of food on absorption of d,1-alpha-tocopheryl nicotinate was studied in cross-over studies with eight beagle dogs and four human volunteers. When 100 mg of alpha-tocopheryl nicotinate in gelatin capsule was administered p.o. to beagle dogs in both a

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