420132

JAK2 Inhibitor II

The JAK2 Inhibitor II, also referenced under CAS 1837-91-8, controls the biological activity of JAK2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• Synonym(e): JAK2 Inhibitor II, 1,2,3,4,5,6-Hexabromocyclohexane
• Empirische Formel (Hill-System): C₆H₆Br₆
• CAS-Nummer: 1837-91-8
• Molekulargewicht: 557.54
• MDL-Nummer: MFCD00059127
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥97% (GC)
• Form: solid
• Hersteller/Markenname: Calbiochem^®
• Lagerbedingungen: OK to freeze; protect from light
• Farbe: off-white
• Löslichkeit: DMSO: 5 mg/mL
• Versandbedingung: ambient
• Lagertemp.: 2-8°C
• InChI: 1S/C6H6Br6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-6H
• InChIKey: QFQZKISCBJKVHI-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

A cell-permeable hexabromocyclohexane compound that interacts with a solvent-accessible pocket near the activation loop of JAK2 and acts as a specific, reversible, and direct inhibitor of JAK2 autophosphorylation (maximal inhibition at 50 µM in BSC-40 cells overexpressing JAK2). Reduces growth hormone-mediated JAK2 activation in γ2A cells that stably express growth hormone receptor and JAK2. Does not block EGFR autophosphorylation in murine fibroblasts.

A cell-permeable, specific, reversible, and direct inhibitor of JAK2 autophosphorylation (maximal inhibition at 50 µM in BSC-40 cells overexpressing JAK2 that interacts with a solvent-accessible pocket near the activation loop of JAK2. Reduces growth hormone-mediated JAK2 activation in γ2A cells that stably express growth hormone receptor and JAK2. Does not block EGFR autophosphorylation in murine fibroblasts.

Biochem./physiol. Wirkung

Cell permeable: yes

Primary Target
JAK2 autophosphorylation

Product does not compete with ATP.

Reversible: yes

Verpackung

Packaged under inert gas

Warnhinweis

Toxicity: Standard Handling (A)

Rekonstituierung

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Sonstige Hinweise

Sandberg, E.M., et al. 2005. J. Med. Chem.48, 2526.

Rechtliche Hinweise

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H302,H319
• P-Sätze: P264 - P280 - P301 + P312 - P305 + P351 + P338 - P337 + P313 - P501
• Gefahreneinstufungen: Acute Tox. 4 Oral - Eye Irrit. 2
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable