SML3747

IM1761092 hydrochloride

≥98% (HPLC)

• Synonym(e): IM 1092 hydrochloride, IM 1761092 hydrochloride, IM-1092 hydrochloride, IM-1761092 hydrochloride, IM1092 hydrochloride, N-1-(3-chloro-4-iodo)phenethylbiguanide hydrochloride
• Empirische Formel (Hill-System): C₁₀H₁₃ClIN₅·HCl
• CAS-Nummer: 1820014-33-2
• Molekulargewicht: 402.06
• UNSPSC-Code: 12352200
• NACRES: NA.21

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Lagerbedingungen: desiccated
• Farbe: white to beige
• Löslichkeit: H₂O: 2 mg/mL, clear
• Lagertemp.: room temp
• SMILES String: ClC1=CC(CCNC(NC(N)=N)=N)=CC=C1I.Cl
• InChIKey: NSBWTYOKPDFWFE-UHFFFAOYSA-N

Beschreibung

Biochem./physiol. Wirkung

Biguanide-based mammalian respiratory complex I inhibitor that exhibits significantly higher potency than metformin and phenformin.

IM1761092 (IM1092) is a biguanide-based mammalian respiratory complex I inhibitor that reduces cellular oxygen consumption (IC50 = 3.6 μM post 6h treatment; HEPG2 C3A cells) and exhibits significantly higher potency than metformin and phenformin (by 10- to 2000-fold depending on the conditions) using bovine heart mitochondrial membrane preparations (IM1092/phenformin/metformin IC50 = 32 μM/3.8 mM/99 mM against active complex I, 4 μM/131 μM/33 mM against deactive complex I).

Vorsicht

Hygroscopic

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable