SML3325

Sob-AM2

≥98% (HPLC)

• Synonym(e): 2-[4-[[4-Hydroxy-3-(1-methylethyl)phenyl]methyl]-3,5-dimethylphenoxy]-N-methylacetamide
• Empirische Formel (Hill-System): C₂₁H₂₇NO₃
• CAS-Nummer: 2128258-47-7
• Molekulargewicht: 341.44
• UNSPSC-Code: 51111800
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to beige
• Löslichkeit: DMSO: 2 mg/mL, clear
• Lagertemp.: 2-8°C
• SMILES String: CC(C1=C(C=CC(CC2=C(C=C(C=C2C)OCC(NC)=O)C)=C1)O)C
• InChI: 1S/C21H27NO3/c1-13(2)18-10-16(6-7-20(18)23)11-19-14(3)8-17(9-15(19)4)25-12-21(24)22-5/h6-10,13,23H,11-12H2,1-5H3,(H,22,24)
• InChIKey: UWVFEENBJKSTRD-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

Sob-AM2 is a methyl amide derivative and a central nervous system (CNS)- selective prodrug of Sobetirome. Even in the absence of monocarboxylate transporter 8 (Mct8), Sob-AM2 can penetrate the brain and exhibit thyromimetic effects. It can promote extensive myelin repair in the brain and spinal cord of mouse models with demyelination. Sob-AM2 and other thyromimetics may also stimulate triggering receptor expressed on myeloid cell-2 (TREM2) expression in macrophages and microglia.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable