SML0743

EUK-134

≥95% (HPLC)

• Synonym(e): (SP-5-13)-Chloro[[2,2′-[1,2-ethanediylbis[(nitrilo-?N)methylidyne]]bis[6-methoxyphenolato-KO]](2-)]-manganese, 2,2′-[1,2-Ethanediylbis(nitrilomethylidyne)]bis[6-methoxy-phenol manganese complex, Chloro[[2,2′-[1,2-ethanediylbis(nitrilomethylidyne)]bis[6-methoxyphenolato]](2-)-N2,N2′,O1,O1′]-manganese, EUK 134
• Empirische Formel (Hill-System): C₁₈H₁₈ClMnN₂O₄
• CAS-Nummer: 81065-76-1
• Molekulargewicht: 416.74
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥95% (HPLC)
• Form: powder
• Lagerbedingungen: desiccated
• Farbe: , faint to very dark brown
• Löslichkeit: H₂O: 2 mg/mL, clear (warmed)
• Lagertemp.: −20°C
• SMILES String: [Mn+2]Cl.N(=Cc2c(c(ccc2)OC)[O-])CCN=Cc1c(c(ccc1)OC)[O-]
• InChI: 1S/C18H20N2O4.ClH.Mn/c1-23-15-7-3-5-13(17(15)21)11-19-9-10-20-12-14-6-4-8-16(24-2)18(14)22;;/h3-8,11-12,21-22H,9-10H2,1-2H3;1H;/q;;+3/p-3
• InChIKey: YUZJJFWCXJDFOQ-UHFFFAOYSA-K

Beschreibung

Anwendung

EUK-134 has been used as an antioxidant.

EUK-134 has been used to determine the mechanism underlying hypoxia-inducible factor-1α (HIF-1α) stabilization in human aortic endothelial cells (HAECs).

Biochem./physiol. Wirkung

EUK-134 is a manganese-salen derivative that exhibit potent antioxidant activities. EUK-134 is a superoxide dismutase (SOD) that inhibits amyloid fibril formation, including islet amyloid polypeptide (IAPP), β-amyloid and lysozyme amyloid aggregation. It appears that EUK-134 disrupts the pre-formed amyloid fibrils. EUK-134 increases the viability of the SK-N-MC cells exposed to preformed IAPP fibrils.

Sonstige Hinweise

air sensitive

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable