SML0654

Entacapon

≥98% (HPLC)

• Synonym(e): 2-Cyan-N,N-diethyl-3-(3,4-dihydroxy-5-nitrophenyl)-propenamid
• Empirische Formel (Hill-System): C₁₄H₁₅N₃O₅
• CAS-Nummer: 130929-57-6
• Molekulargewicht: 305.29
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to light brown
• Löslichkeit: DMSO: 20 mg/mL, clear
• Lagertemp.: room temp
• SMILES String: [N+](=O)([O-])c1c(c(cc(c1)\C=C(\C(=O)N(CC)CC)/C#N)O)O
• InChI: 1S/C14H15N3O5/c1-3-16(4-2)14(20)10(8-15)5-9-6-11(17(21)22)13(19)12(18)7-9/h5-7,18-19H,3-4H2,1-2H3/b10-5+
• InChIKey: JRURYQJSLYLRLN-BJMVGYQFSA-N

Beschreibung

Anwendung

Entacapone has been used in high-performance bioaffinity chromatography.

Biochem./physiol. Wirkung

Entacapone acts predominantly in the intestine. It increases the bioavailability of levodopa. Levodopa is known to be associated with many complications such as motor fluctuations. COMT inhibitors have been used to overcome these adverse effects of levodopa by reducing its metabolism. Entacapone exhibits its inhibition action on COMT in the peripheral nervous system.

Entacapone is a catechol-O-methyl transferase (COMT) inhibitor. Used in treatment of Parkinson′s disease, entacapone is administered with L-DOPA to inihibit COMT from converting L-DOPA into a compound that cannot cross the blood brain barrier.

Leistungsmerkmale und Vorteile

This compound is featured on the Dopamine and Norepinephrine Metabolism page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable