T2573

Troglitazone

≥98% (HPLC), powder, PPARγ agonist

• Synonym(e): (±)-5-[4-[(6-Hydroxy-2,5,7,8-tetramethylchroman-2-yl)methoxy]benzyl]-2,4-thiazolidinedione, CS-045
• Empirische Formel (Hill-System): C₂₄H₂₇NO₅S
• CAS-Nummer: 97322-87-7
• Molekulargewicht: 441.54
• MDL-Nummer: MFCD00878416
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24724629
• NACRES: NA.77

Eigenschaften

• product name: Troglitazone, ≥98% (HPLC)
• Qualitätsniveau: 200
• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to off-white
• Löslichkeit: DMSO: 20 mg/mL
• SMILES String: Cc1c(C)c2OC(C)(CCc2c(C)c1O)COc3ccc(CC4SC(=O)NC4=O)cc3
• InChI: 1S/C24H27NO5S/c1-13-14(2)21-18(15(3)20(13)26)9-10-24(4,30-21)12-29-17-7-5-16(6-8-17)11-19-22(27)25-23(28)31-19/h5-8,19,26H,9-12H2,1-4H3,(H,25,27,28)
• InChIKey: GXPHKUHSUJUWKP-UHFFFAOYSA-N
• Angaben zum Gen: human ... PPARA(5465) , PPARG(5468)

Beschreibung

Allgemeine Beschreibung

Troglitazone is used to treat type 2 diabetes. It is associated with liver injury. Troglitazone functions as an inducer of cytochrome3A.

Anwendung

Troglitazone has been used as a reagent in adipocyte differentiation medium.

Biochem./physiol. Wirkung

PPARγ agonist; anti-diabetic thiazolidinedione (TZD) with anti-inflammatory and anti-tumor activity; induces apoptosis via a p53 pathway.

Leistungsmerkmale und Vorteile

This compound is featured on the Nuclear Receptors (PPARs) and Potassium Channels pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Angaben zur Herstellung

Studies using troglitazone have reported that it can increase AMP-activated protein kinase (pAMPK) and phosphorylated acetyl-CoA carboxylase in isolated rat extensor digitorum longus muscles¹. Furthermore, analysis of troglitazone-mediated autophagy is reported to correlate with the stimulation of AMPK α².

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 2
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)