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SML0582

Sigma-Aldrich

Hispidulin

≥98% (HPLC)

Synonym(e):

4′,5,7-Trihydroxy-6-methoxyflavon, 6-Methoxyapigenin, 6-Methylscutellarein, Dinatin, Salvitin, Scutellarein-6-methylether

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About This Item

Empirische Formel (Hill-System):
C16H12 O6
CAS-Nummer:
1447-88-7
Molekulargewicht:
300.26
MDL-Nummer:
MFCD00143504
UNSPSC-Code:
12352200
NACRES:
NA.77

Qualitätsniveau

100

Assay

≥98% (HPLC)

Form

powder

Lagerbedingungen

desiccated

Farbe

white to beige

Löslichkeit

DMSO: 20 mg/mL, clear

Lagertemp.

−20°C

SMILES String

OC1=C(OC)C(O)=C(C(C=C(C2=CC=C(O)C=C2)O3)=O)C3=C1

InChI

1S/C16H12O6/c1-21-16-11(19)7-13-14(15(16)20)10(18)6-12(22-13)8-2-4-9(17)5-3-8/h2-7,17,19-20H,1H3

InChIKey

IHFBPDAQLQOCBX-UHFFFAOYSA-N

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Anwendung

Hispidulin has been used as a calibration standard:
  • in high-performance liquid chromatography (HPLC) for quantification of Clerodendrum petasites flavonoids
  • in liquid chromatography/electrospray ionization mass spectrometry (LC/ESI-MS) analysis
  • in reverse-phase high-performance liquid chromatography with a diode-array detector (HPLC-DAD) and high-performance thin-layer chromatography (HPTLC)

Biochem./physiol. Wirkung

Hispidulin also exhibits antiosteoporotic anti-atheromatous, antispasmodic and anticancer functionality. It exhibits inhibition on α-glucosidase enzymatic activity. Hispidulin inhibits platelet aggregation and is more effective than theophylline. It also acts as a modulator of the γ-aminobutyric acid receptor (GABA) and blocks the release of glutamate synaptosomes associated with cortical neurons.
Hispidulin is a bioactive flavonoid with a variety of effects including antiproliferative, antifungal, anti-inflammatory, antioxidative and antiepileptic activity. Like EGCG, hispidulin appears to activate AMPK and inhibit the PI3K/Akt/mTOR pathway. The antiepileptic activity may be due to additional activity as a benzodiazepine (BZD) receptor ligand.

Leistungsmerkmale und Vorteile

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number
0000186197
026M4734V
043M4709V

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Sesamolin ≥97%, from Sesamum indicum (sesame)

Sigma-Aldrich

SMB00701

Sesamolin

Liquiritigenin ≥97.0% (HPLC)

Sigma-Aldrich

78825

Liquiritigenin

Formononetin analytical standard

Supelco

94334

Formononetin

Luteolin ≥98% (TLC), powder

Sigma-Aldrich

L9283

Luteolin

(−)-Epigallokatechingallat ≥80% (HPLC), from green tea

Sigma-Aldrich

E4268

(−)-Epigallokatechingallat

Rosmarinsäure ≥98% (HPLC), from Rosemarinus officinalis L.

Sigma-Aldrich

R4033

Rosmarinsäure

Apigenin ≥95.0% (HPLC)

Sigma-Aldrich

10798

Apigenin

Priscila Dabaghi-Barbosa et al.
Free radical research, 39(12), 1305-1315 (2005-11-22)
Hispidulin (6-methoxy-5,7,4'-trihydroxyflavone) and eupafolin (6-methoxy-5,7,3',4'-tetrahydroxyflavone), are flavonoids found in the leaves of Eupatorium litoralle. They have recognized antioxidant and antineoplastic properties, although their action mechanisms have not been previously described. We now report the effects of hispidulin on the oxidative
A Hazekamp et al.
Journal of ethnopharmacology, 78(1), 45-49 (2001-10-05)
The ethanolic extract of Clerodendrum petasites was tested to evaluate the spasmolytic activity on isolated guinea-pig tracheal smooth muscle. The crude extract (2.25-9.0 mg/ml) dose-dependently caused relaxation of tracheal smooth muscle which was contracted by exposure to histamine. A bioassay-guided
L D Zhou et al.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 26(2), 114-117 (2003-01-15)
To study the chemical constituents the roots of Chirita fimbrisepala. The constituents were extracted with solvent, separated and purified with chromatographic methods, identified by NMR, MS, UV, IR and physical-chemical constants. Three flavonoids mahuangchiside(I), hispidulin (II) and kaempferol(III) were isolated
Laurie P Sutton et al.
The international journal of neuropsychopharmacology, 15(7), 965-979 (2011-07-23)
The dopamine D2 receptor (D2DR) regulates Akt and may also target the Wnt pathway, two signalling cascades that inhibit glycogen synthase kinase-3 (GSK-3). This study examined whether the Wnt pathway is regulated by D2DR and the role of Akt and
Chun-xiang Fu et al.
Biotechnology letters, 27(2), 91-95 (2005-02-11)
Three previously established cell lines (yellow, red and white) of Saussurea medusa were investigated for jaceosidin and hispidulin production. Maximum yields of the jaceosidin and hispidulin were obtained in the red cell line at 75+/-0.41 and 6.4+/-0.31 mg l-1. Production
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