SML0097

Nevirapin

• Synonym(e): 11-Cyclopropyl-5,11-dihydro-4-methyl-6H-dipyrido[3,2-b:2′,3′-e][1,4]diazepin-6-one
• Empirische Formel (Hill-System): C₁₅H₁₄N₄O
• CAS-Nummer: 129618-40-2
• Molekulargewicht: 266.30
• MDL-Nummer: MFCD00866928
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329825155
• NACRES: NA.77

Eigenschaften

• Assay: ≥98% (HPLC)
• Qualitätsniveau: 100
• Form: powder
• Farbe: white to tan
• Löslichkeit: DMSO: ≥22 mg/mL
• Lagertemp.: room temp
• SMILES String: CC1=CC=NC2=C1NC(C(C=CC=N3)=C3N2C4CC4)=O
• InChI: 1S/C15H14N4O/c1-9-6-8-17-14-12(9)18-15(20)11-3-2-7-16-13(11)19(14)10-4-5-10/h2-3,6-8,10H,4-5H2,1H3,(H,18,20)
• InChIKey: NQDJXKOVJZTUJA-UHFFFAOYSA-N

Beschreibung

Anwendung

Nevirapine has been used as non-nucleoside reverse transcriptase inhibitor in in vitro porcine endogenous retrovirus replication, primary hepatocytes and bone marrow dendritic cells (BMDCs).

Biochem./physiol. Wirkung

Nevirapine interacts with glycine 190 residue of human immuno deficiency virus (HIV-2) reverse transcriptase. It is an antiretroviral drug which increases bile synthesis and activates electron transport chain. Use of nevirapine leads to liver toxicity and is associated with Nevirapine hypersensitivity syndrome.

Nevirapine is an allosteric, non-nucleoside inhibitor of HIV reverse transcriptase (NNRTI). The K_i for inhibition of wild-type RT by Nevirapine is 200 nM.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 2
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable