SML0036

Procarbazin -hydrochlorid

≥98% (HPLC)

• Synonym(e): N-(1-Methylethyl)-4-[(2-methylhydrazinyl)-methyl]-benzamid -hydrochlorid
• Empirische Formel (Hill-System): C₁₂H₁₉N₃O·HCl
• CAS-Nummer: 366-70-1
• Molekulargewicht: 257.76
• EG-Nummer: 206-678-6
• MDL-Nummer: MFCD00072082
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329825106
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Lagerbedingungen: desiccated
• Farbe: white to tan
• Löslichkeit: DMSO: ≥18 mg/mL
• Lagertemp.: 2-8°C
• SMILES String: Cl.CNNCc1ccc(cc1)C(=O)NC(C)C
• InChI: 1S/C12H19N3O.ClH/c1-9(2)15-12(16)11-6-4-10(5-7-11)8-14-13-3;/h4-7,9,13-14H,8H2,1-3H3,(H,15,16);1H
• InChIKey: DERJYEZSLHIUKF-UHFFFAOYSA-N

Beschreibung

Anwendung

Procarbazine hydrochloride has been used to study its physicochemical property.

Procarbazine, an antineoplastic alkylating agent, may be used to study its pharmacokinetics, metabolism, safety, efficacy and methods of delivery as an anticancer agent. It may be used to study new combination of anticancer drugs.

Biochem./physiol. Wirkung

Procarbazine is an antineoplastic alkylating agent widely used in cancer chemotherapy in combination with other compounds. It has multiple mechanisms of action. Procarbazine inhibits protein, RNA and DNA synthesis in addition to being an alkylating agent.

Procarbazine is metabolized to azoprocarbazine either by cytochrome P450 enzyme and monoamine oxidase in an NADPH (nicotinamide adenine diphosphate) dependent or independent manner. It is considered neurotoxic. Procarbazine is used in combination with therapy for treating Hodgkin′s disease.

Sicherheitshinweise

• Piktogramme: GHS08,GHS07
• Signalwort: Danger
• H-Sätze: H302,H341,H350,H360
• P-Sätze: P201 - P301 + P312 + P330 - P308 + P313
• Gefahreneinstufungen: Acute Tox. 4 Oral - Carc. 1B - Muta. 2 - Repr. 1A
• Lagerklassenschlüssel: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable